Linked Life Data

11516910

Source:http://linkedlifedata.com/resource/pubmed/id/11516910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-8-22
pubmed:abstractText
The controlled adsorptive accumulation of Zn(II)-terfenadine complex (1:1) onto a hanging mercury drop electrode (HMDE) provides the basis for determination of the antihistamine drug terfenadine by differential pulse cathodic adsorptive stripping voltammetry. The adsorbed Zn(II)-terfenadine complex (1:1) at the HMDE developed a stripping voltammetry peak at more negative potential than that of the free Zn(II) ions. The peak current was used for the determination of terfenadine in pharmaceutical formulation and human plasma in 0.1 mol l(-1) sodium perchlorate solution under the optimized conditions (E(acc), -0.5 V; t(acc) 360 s; scan rate, 5 mV s(-1) and pulse height 100 mV). The developed peak current (i(p)) showed a linear dependence with terfenadine concentration within the range of 6 x 10(-8) - 9 x 10(-7) mol l(-1). The recoveries were found 98.97-99.35%, 99.72-99.02% and 100.58-101.08% with the R.S.D. 0.16-0.27%, 0.25-0.82% and 0.44-1.14% in authentic form, pharmaceutical formulations and human plasma, respectively. The detection limits were 0.4505 and 0.6115 ng ml(-1) terfenadine in pharmaceutical formulations and human plasma, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
593-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Assay of terfenadine in pharmaceutical formulation and human plasma by adsorptive stripping voltammetry.
pubmed:affiliation
Chemistry Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt. mmghoneim@usa.net
pubmed:publicationType
Journal Article