| pubmed-article:11496110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11496110 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11496110 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11496110 | lifeskim:mentions | umls-concept:C0034843 | lld:lifeskim |
| pubmed-article:11496110 | lifeskim:mentions | umls-concept:C0596131 | lld:lifeskim |
| pubmed-article:11496110 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11496110 | pubmed:dateCreated | 2001-8-9 | lld:pubmed |
| pubmed-article:11496110 | pubmed:abstractText | As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse strains where AGS is age-restricted. Thrb(tm1/tm1) mice display AGS whether on a mixed 129/Sv x C57BL/6J or congenic C57BL/6J background. 27% of wild-type mice on the mixed and 0% on the congenic background exhibited AGS. The inability of Thrb(tm1/tm1) mice to downregulate the response to sustained acoustic stimulation may reside in the brain or in the auditory system itself as Thrb(tm1/tm1) mice also display auditory deficits. The AGS phenotype identifies a novel neurological role for TR beta. | lld:pubmed |
| pubmed-article:11496110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11496110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11496110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11496110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11496110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11496110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11496110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11496110 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11496110 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:Morreale de... | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:VennströmBB | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:RUER ERE | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:CurranTT | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:ForrestDD | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:FarisJ SJS | lld:pubmed |
| pubmed-article:11496110 | pubmed:author | pubmed-author:PedrazaP EPE | lld:pubmed |
| pubmed-article:11496110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11496110 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:11496110 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:11496110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11496110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11496110 | pubmed:pagination | 2359-62 | lld:pubmed |
| pubmed-article:11496110 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:meshHeading | pubmed-meshheading:11496110... | lld:pubmed |
| pubmed-article:11496110 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11496110 | pubmed:articleTitle | Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice. | lld:pubmed |
| pubmed-article:11496110 | pubmed:affiliation | Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:11496110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11496110 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11496110 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21833 | entrezgene:pubmed | pubmed-article:11496110 | lld:entrezgene |
| entrez-gene:21834 | entrezgene:pubmed | pubmed-article:11496110 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11496110 | lld:pubmed |
