Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-8-8
pubmed:abstractText
Dorsal-ventral polarity of the Drosophila embryo is established by a nuclear gradient of Dorsal protein, generated by successive gurken-Egfr and spätzle-Toll signaling. Overexpression of extracellular Spätzle dramatically reshapes the Dorsal gradient: the normal single peak is broadened and then refined to two distinct peaks of nuclear Dorsal, to produce two ventral furrows. This partial axis duplication, which mimics the ventralized phenotype caused by reduced gurken-Egfr signaling, arises from events in the perivitelline fluid of the embryo and occurs at the level of Spätzle processing or Toll activation. The production of two Dorsal peaks is addressed by a model that invokes action of a diffusible inhibitor, which is proposed to normally regulate the slope of the Dorsal gradient.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Sulfotransferases, http://linkedlifedata.com/resource/pubmed/chemical/Tl protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factors, http://linkedlifedata.com/resource/pubmed/chemical/gurken protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/pipe protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/spatzle protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2309-19
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11493550-Animals, pubmed-meshheading:11493550-Body Patterning, pubmed-meshheading:11493550-Drosophila Proteins, pubmed-meshheading:11493550-Drosophila melanogaster, pubmed-meshheading:11493550-Female, pubmed-meshheading:11493550-Gene Expression Regulation, Developmental, pubmed-meshheading:11493550-Gene Expression Regulation, Enzymologic, pubmed-meshheading:11493550-Insect Proteins, pubmed-meshheading:11493550-Membrane Glycoproteins, pubmed-meshheading:11493550-Oogenesis, pubmed-meshheading:11493550-Receptor, Epidermal Growth Factor, pubmed-meshheading:11493550-Receptors, Cell Surface, pubmed-meshheading:11493550-Signal Transduction, pubmed-meshheading:11493550-Sulfotransferases, pubmed-meshheading:11493550-Toll-Like Receptors, pubmed-meshheading:11493550-Transforming Growth Factor alpha, pubmed-meshheading:11493550-Transforming Growth Factors
pubmed:year
2001
pubmed:articleTitle
Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo.
pubmed:affiliation
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. dmorisato@mhs.harvard.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.