Source:http://linkedlifedata.com/resource/pubmed/id/11488324
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-8-7
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| pubmed:abstractText |
The natural history of the development of sensitization and disease due to high-molecular-weight allergens is not well characterized. This study describes the time-course of the incidence of work-related symptoms, skin reactivity and occupational rhinoconjunctivitis (RC) and asthma (OA); and assesses the predictive value of skin testing and RC symptoms in apprentices exposed to laboratory animals, in a 3-4-yr programme. Four-hundred and seventeen apprentices at five institutions were assessed prospectively with questionnaire, skin-testing with animal-derived allergens, spirometry and airway responsiveness (n=373). Depending on the school, students were seen 8 (n=136), 20 (n=345), 32 (n=355) and 44 (n=98) months after starting the programme. At all visits, the incidence was greater for work-related RC symptoms followed in order by skin reactivity, occupational RC, and, almost equally, OA and work-related respiratory symptoms. The incidence-density figures were comparable for each follow-up period and for most indices up to 32 months after entry into the study and then tended to decrease. The positive predictive values (PPVs) of skin reactivity to work-related allergens for the development of work-related RC and respiratory symptoms were 30% and 9.0%, respectively, while the PPVs of work-related RC for the development of OA was 11.4%. Sensitization, symptoms and diseases occur maximally in the first 2-3 yrs after starting exposure to laboratory animals. Skin reactivity to work-related allergens and rhinoconjuctivitis symptoms have low positive predictive values.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0903-1936
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
904-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11488324-Adolescent,
pubmed-meshheading:11488324-Adult,
pubmed-meshheading:11488324-Allergens,
pubmed-meshheading:11488324-Animals,
pubmed-meshheading:11488324-Animals, Laboratory,
pubmed-meshheading:11488324-Asthma,
pubmed-meshheading:11488324-Cohort Studies,
pubmed-meshheading:11488324-Conjunctivitis, Allergic,
pubmed-meshheading:11488324-Female,
pubmed-meshheading:11488324-Follow-Up Studies,
pubmed-meshheading:11488324-Forced Expiratory Volume,
pubmed-meshheading:11488324-Humans,
pubmed-meshheading:11488324-Intradermal Tests,
pubmed-meshheading:11488324-Male,
pubmed-meshheading:11488324-Occupational Diseases,
pubmed-meshheading:11488324-Reference Values,
pubmed-meshheading:11488324-Rhinitis, Allergic, Perennial,
pubmed-meshheading:11488324-Vital Capacity,
pubmed-meshheading:11488324-Vocational Education
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Natural history of sensitization, symptoms and occupational diseases in apprentices exposed to laboratory animals.
|
| pubmed:affiliation |
Dept of Chest Medicine, H?pital du Sacré-Coeur, Montreal, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|