Source:http://linkedlifedata.com/resource/pubmed/id/11459318
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2001-7-18
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| pubmed:abstractText |
Although oral candidiasis is frequently seen in the elderly, the factors determining candidal growth have insufficiently been explored. Hence, we examined the influence of aging on candidal adhesion and growth-inhibitory agents in saliva in 45 healthy volunteers and 60 patients with oral candidiasis. Both non-stimulated and stimulated salivary flow rates (SFRs) in the healthy controls decreased with aging. A gradual decrease of SFRs with aging was also observed in the patients, and the SFR levels were markedly lower than those in the controls. Although the salivary glucose levels were almost constant in all age groups, secretory immunoglobulin A and lactoferrin levels in saliva were significantly decreased statistically with age, and a marginal age-associated decrease in transferrin levels was also observed. In addition, the generation of superoxide from neutrophils in saliva and their Candida killing activity decreased with age, and these phenomena were more apparent in the patients. Furthermore, a larger number of Candida adhered to oral keratinocytes obtained from the elderly healthy controls than to those obtained from young controls. Correspondingly, keratinocytes from the aged controls showed more concanavalin-A binding sites than those from the young controls. However, oral Candida did not increase with increasing age in the controls, although an age-associated increase of oral Candida was observed in the patients. Taken together, these results indicate that the decreases of SFRs and salivary anti-candidal factors, suppression of salivary neutrophil function and the increase of candidal adhesion sites on keratinocytes predispose elderly individuals to oral candidiasis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A, Secretory,
http://linkedlifedata.com/resource/pubmed/chemical/Lactoferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0904-2512
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
328-35
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11459318-Adult,
pubmed-meshheading:11459318-Aged,
pubmed-meshheading:11459318-Aged, 80 and over,
pubmed-meshheading:11459318-Aging,
pubmed-meshheading:11459318-Candida albicans,
pubmed-meshheading:11459318-Candidiasis, Oral,
pubmed-meshheading:11459318-Cell Culture Techniques,
pubmed-meshheading:11459318-Colony Count, Microbial,
pubmed-meshheading:11459318-Concanavalin A,
pubmed-meshheading:11459318-Female,
pubmed-meshheading:11459318-Glucose,
pubmed-meshheading:11459318-Humans,
pubmed-meshheading:11459318-Immunoglobulin A, Secretory,
pubmed-meshheading:11459318-Keratinocytes,
pubmed-meshheading:11459318-Lactoferrin,
pubmed-meshheading:11459318-Male,
pubmed-meshheading:11459318-Middle Aged,
pubmed-meshheading:11459318-Mouth Mucosa,
pubmed-meshheading:11459318-Neutrophils,
pubmed-meshheading:11459318-Receptors, Concanavalin A,
pubmed-meshheading:11459318-Risk Factors,
pubmed-meshheading:11459318-Saliva,
pubmed-meshheading:11459318-Secretory Rate,
pubmed-meshheading:11459318-Statistics as Topic,
pubmed-meshheading:11459318-Superoxides,
pubmed-meshheading:11459318-Transferrin
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| pubmed:year |
2001
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| pubmed:articleTitle |
Influence of aging on candidal growth and adhesion regulatory agents in saliva.
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| pubmed:affiliation |
Department of Oral Surgery, Kochi Medical School, Japan.
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| pubmed:publicationType |
Journal Article
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