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| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C1366753 | lld:lifeskim |
| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C0205548 | lld:lifeskim |
| pubmed-article:11448165 | lifeskim:mentions | umls-concept:C1548425 | lld:lifeskim |
| pubmed-article:11448165 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11448165 | pubmed:dateCreated | 2001-7-12 | lld:pubmed |
| pubmed-article:11448165 | pubmed:abstractText | We examined the influence on the interferon (IFN) signaling pathway of infection with herpes simplex virus type 1 (HSV-1) strain VR3. Data from reporter gene assays showed that expression of both type I and type II IFN-inducible genes was dramatically suppressed during the early stage of HSV-1 infection (2 to 3 h postinfection). During these periods, phosphorylation levels of janus kinases (JAKs) and STATs did not increase after treatment of HSV-1-infected FL cells with IFN-alpha or IFN-gamma, although cellular protein levels of the JAKs and the STATs were not significantly changed. In contrast, the inhibitory effect of HSV-1 on phosphorylation of STAT1 was not observed in U937 cells, which show resistance to steady-state accumulation of RNA for HSV-1 immediate-early genes. The phosphorylation of STAT1 in FL cells was not inhibited by infection with a UV-inactivated virus. These results indicate that viral gene expression or viral protein production is necessary for the inhibition of phosphorylation by HSV-1. | lld:pubmed |
| pubmed-article:11448165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11448165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448165 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11448165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11448165 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11448165 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:KubotaTT | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:MiuraSS | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:FujiiNN | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:YoshidaII | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:YokosawaNN | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:JimbowKK | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:SuzutaniTT | lld:pubmed |
| pubmed-article:11448165 | pubmed:author | pubmed-author:Yokota SS | lld:pubmed |
| pubmed-article:11448165 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11448165 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11448165 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11448165 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:11448165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11448165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11448165 | pubmed:pagination | 119-24 | lld:pubmed |
| pubmed-article:11448165 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11448165 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11448165 | pubmed:articleTitle | Herpes simplex virus type 1 suppresses the interferon signaling pathway by inhibiting phosphorylation of STATs and janus kinases during an early infection stage. | lld:pubmed |
| pubmed-article:11448165 | pubmed:affiliation | Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, 060-8556, Japan. syokota@sapmed.ac.jp | lld:pubmed |
| pubmed-article:11448165 | pubmed:publicationType | Journal Article | lld:pubmed |
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