Linked Life Data

11442647

Source:http://linkedlifedata.com/resource/pubmed/id/11442647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-7-9
pubmed:abstractText
A mild haemophilia A (factor VIII [FVIII] 10%) was discovered in a 73-year-old man during the preoperative haemostasis tests before a total knee arthroplasty for treatment of degenerative senile arthropathy. No history of previous abnormal bleeding was noted in spite of several previous challenging surgical procedures. Acquired haemophilia was ruled out and no other cases of haemophilia were found in the family. The surgery was successfully performed under recombinant FVIII aimed at achieving an FVIII level above 60%. This therapy induced the transient appearance of low-titre FVIII antibodies. A still unpublished mutation within the exon 3 (Gly73Ala) was found with molecular studies. This case report underlines the importance of haemostasis tests before high-risk bleeding surgical procedures even in elderly patients without a past history of haemorrhagic tendency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1351-8216
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-21
pubmed:dateRevised
2009-10-21
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Mild haemophilia A discovered in a previously multi-operated 73-year-old man: characterization of a new mutation.
pubmed:affiliation
Department of Haematology, Centre Hospitalier de la Côte Basque, Bayonne, France.
pubmed:publicationType
Journal Article, Case Reports