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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2001-6-20
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pubmed:abstractText |
Reovirus is a naturally occurring oncolytic virus that usurps activated Ras-signaling pathways of tumor cells for its replication. Ras pathways are activated in most malignant gliomas via upstream signaling by receptor tyrosine kinases. The purpose of this study was to determine the effectiveness of reovirus as an experimental treatment for malignant gliomas.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8874
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pubmed:author |
pubmed-author:BrasherP MPM,
pubmed-author:ForsythP APA,
pubmed-author:JohnstonR NRN,
pubmed-author:LeeP WPW,
pubmed-author:MorrisD GDG,
pubmed-author:NishikawaSS,
pubmed-author:RewcastleN BNB,
pubmed-author:RhoY MYM,
pubmed-author:SengerDD,
pubmed-author:WilcoxM EME,
pubmed-author:YangWW
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
903-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11416111-Animals,
pubmed-meshheading:11416111-Brain Neoplasms,
pubmed-meshheading:11416111-Female,
pubmed-meshheading:11416111-Glioma,
pubmed-meshheading:11416111-Humans,
pubmed-meshheading:11416111-Male,
pubmed-meshheading:11416111-Mammalian orthoreovirus 3,
pubmed-meshheading:11416111-Mice,
pubmed-meshheading:11416111-Mice, Inbred NOD,
pubmed-meshheading:11416111-Mice, Nude,
pubmed-meshheading:11416111-Mice, SCID,
pubmed-meshheading:11416111-Survival Rate,
pubmed-meshheading:11416111-Transplantation, Heterologous,
pubmed-meshheading:11416111-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Reovirus as an oncolytic agent against experimental human malignant gliomas.
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pubmed:affiliation |
Departments of Oncology and Clinical Neurosciences, University of Calgary, and Tom Baker Cancer Centre, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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