Linked Life Data

11411045

Source:http://linkedlifedata.com/resource/pubmed/id/11411045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-6-19
pubmed:abstractText
In vitro effect of aluminium (Al) on Fe(2+)-induced lipid peroxidation (LPX) in various subcellular fractions from the cerebral hemispheres (CH) of 7- and 30-day old chicks was studied. Stimulation of Fe(2+)-induced LPX by Al was observed to be the highest in microsomal fraction. The magnitude of elevation of Fe(2+)-induced LPX in various subcellular fractions of brain showed age related variation. Of the six chemicals tested for their influence on Al-induced lipid peroxidation, both doses of 1,2-dihydroxybenzene-3,5-disulphonic acid disodium salt (Tiron), ethylene diamine tetra acetic acid disodium salt (EDTA), and ascorbic acid prevented the Al-induced LPX in crude homogenates of the CH, whereas only at a higher dose inhibition by 1,4-diazabicyclo (2.2.2.) octan (DABCO) was observed. On the contrary, mannitol and dimethyl sulfoxide did not inhibit the induction of LPX by Al in crude homogenate. The effect of test chemicals on Al-induced LPX in both the ages of chick tissue was almost similar. The results suggest that Al further augments Fe(2+)-induced LPX in various compartments of the cell due to generation of free radicals. The results also showed that Tiron, EDTA and antioxidants, such as ascorbic acid and DABCO can prevent LPX induced by Al.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0019-5189
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1231-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
In vitro stimulation of chick brain lipid peroxidation by aluminium, and effects of tiron, EDTA and some antioxidants.
pubmed:affiliation
Department of Zoology, S C S College, Puri 752001, India.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't