Linked Life Data

11410112

Source:http://linkedlifedata.com/resource/pubmed/id/11410112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-6-18
pubmed:abstractText
The effects of glucose-insulin-potassium (GIK) on cardiac metabolism have been studied previously in non-diabetic patients after cardiac surgery. Although patients with diabetes mellitus can be expected to benefit most from such treatment, the impact of GIK in diabetic patients undergoing cardiac surgery remains unexplored. Therefore the present study investigates the effects of high-dose GIK on myocardial substrate utilization after coronary surgery in patients with Type II diabetes. A total of 20 patients with Type II diabetes undergoing elective coronary surgery were randomly allocated to either post-operative high-dose GIK or standard post-operative care, including insulin infusion if necessary to keep blood glucose below 10 mmol/l. Myocardial substrate utilization was studied using the coronary sinus catheter technique. Haemodynamic state was assessed with the aid of Swan-Ganz catheters. High-dose GIK caused a shift towards carbohydrate utilization, with significant lactate uptake throughout the study period and significant uptake of glucose after 4 h. Arterial levels of non-esterified fatty acids and beta-hydroxybutyric acid decreased, and after 1 h no significant uptake of these substrates was found. Increases in the cardiac index and stroke volume index were found in patients treated with high-dose GIK. A decrease in systemic vascular resistance was found both in the control group and in the high-dose GIK group. We conclude that high-dose GIK can be used in diabetic patients after cardiac surgery to promote carbohydrate uptake at the expense of non-esterified fatty acids and beta-hydroxybutyric acid. This could have implications for treatment of the diabetic heart in association with surgery and ischaemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-43
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11410112-3-Hydroxybutyric Acid, pubmed-meshheading:11410112-Aged, pubmed-meshheading:11410112-Analysis of Variance, pubmed-meshheading:11410112-Angina Pectoris, pubmed-meshheading:11410112-Cardiopulmonary Bypass, pubmed-meshheading:11410112-Catheterization, Central Venous, pubmed-meshheading:11410112-Catheterization, Swan-Ganz, pubmed-meshheading:11410112-Diabetes Mellitus, Type 2, pubmed-meshheading:11410112-Fatty Acids, Nonesterified, pubmed-meshheading:11410112-Female, pubmed-meshheading:11410112-Glucose, pubmed-meshheading:11410112-Glycerol, pubmed-meshheading:11410112-Hemodynamics, pubmed-meshheading:11410112-Humans, pubmed-meshheading:11410112-Insulin, pubmed-meshheading:11410112-Lactic Acid, pubmed-meshheading:11410112-Male, pubmed-meshheading:11410112-Middle Aged, pubmed-meshheading:11410112-Myocardium, pubmed-meshheading:11410112-Potassium, pubmed-meshheading:11410112-Statistics, Nonparametric, pubmed-meshheading:11410112-Stroke Volume, pubmed-meshheading:11410112-Thermodilution, pubmed-meshheading:11410112-Vascular Resistance
pubmed:year
2001
pubmed:articleTitle
Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with Type II diabetes.
pubmed:affiliation
Department of Cardiothoracic Anaesthesia, Linköping Heart Centre, University Hospital, S-581 85 Linköping, Sweden. Zoltan.Szabo@lio.se
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't