Linked Life Data

11406922

Source:http://linkedlifedata.com/resource/pubmed/id/11406922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
120
pubmed:dateCreated
2001-6-15
pubmed:abstractText
Vascular dementia (VaD) describes dementia arising from cerebrovascular disease (CVD) and ischaemic brain injury, and relates to a number of different vascular mechanisms and clinical manifestations. The characterisation of brain lesions by neuroimaging analysis, and the study of their relation to clinical deficits such as cognitive and functional decline, are critical to the concept and treatment of VaD, and form an important part of widely used diagnostic criteria for this dementia type. For instance, the extent to which pathological brain lesions cause, compound or coexist with cognitive impairment is a major determinant of other clinical deficits, their nature and the rate of disease progression. Through numerous neuroimaging and epidemiological studies, VaD is now seen to encompass a heterogeneous group of clinical syndromes such as multiple-infarct (cortical) dementia, small-vessel (subcortical) dementia and, less commonly, dementia associated with strategic infarcts. Due to a large number of similarities in clinical symptoms, pathophysiological mechanisms, associated risk factors and neurochemical deficits between VaD and Alzheimer's disease, patients with coexistent Alzheimer's disease and CVD ('mixed' dementia) represent another important, but previously underestimated subgroup. This article reviews the clinical symptoms and neuroimaging findings most commonly observed in patients with VaD. Increased familiarity with the clinical picture of VaD should offer more hope of defining realistic treatment aims for future pharmacotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1368-504X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-23
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Clinical deficits of Alzheimer's disease with cerebrovascular disease and probable VaD.
pubmed:affiliation
Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland.
pubmed:publicationType
Journal Article, Review