| pubmed-article:11401854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C1179517 | lld:lifeskim |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C0694891 | lld:lifeskim |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11401854 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11401854 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11401854 | pubmed:dateCreated | 2001-6-12 | lld:pubmed |
| pubmed-article:11401854 | pubmed:abstractText | Transforming growth factor-beta (TGF-beta) inhibits pancreatic acinar cell growth. In many cell types, TGF-beta mediates its growth inhibitory effects by activation of Smad proteins. Recently, it has been reported that Smad proteins may interact with the mitogen-activated protein (MAP) kinase signaling pathways. In this study, we report on the interactions between the TGF-beta and MAP kinase signaling pathways in isolated rat pancreatic acinar cells. TGF-beta activated the MAP kinases extracellular signal-related kinases (ERKs) and p38 in pancreatic acinar cells, but had no effect on c-jun NH2-terminal kinase activity. Activation of MAP kinase by TGF-beta was maximal 4 h after treatment. The ability of TGF-beta to activate ERKs was concentration dependent and dependent on protein synthesis. TGF-beta's stimulation of ERK activation was blocked by PD-98059, an inhibitor of MAP kinase kinase 1, and by adenoviral transfer of dominant negative RasN17. Furthermore, adenoviral-mediated expression of dominant negative Smad4 blocked the ability of TGF-beta to activate acinar cell MAP kinase, demonstrating that this activation is downstream of Smads. The biological relevance of ERK activation by TGF-beta was indicated by demonstrating that inhibition of ERK signaling by PD-98059 blocked the ability of TGF-beta to activate the transcription factor activator protein-1. These studies provide new insight into the signaling mechanisms by which TGF-beta mediates biological actions in pancreatic acinar cells. | lld:pubmed |
| pubmed-article:11401854 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11401854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11401854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11401854 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11401854 | pubmed:issn | 0363-6143 | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:SchaeferCC | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:ZhangLL | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:GrazianiAA | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:LogsdonC DCD | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:PhamTT | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:SimeoneD MDM | lld:pubmed |
| pubmed-article:11401854 | pubmed:author | pubmed-author:NickeBB | lld:pubmed |
| pubmed-article:11401854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11401854 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:11401854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11401854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11401854 | pubmed:pagination | C311-9 | lld:pubmed |
| pubmed-article:11401854 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11401854 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11401854 | pubmed:articleTitle | Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. | lld:pubmed |
| pubmed-article:11401854 | pubmed:affiliation | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. simeone@umich.edu | lld:pubmed |
| pubmed-article:11401854 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11401854 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11401854 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11401854 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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