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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
During cardiac ischemia-reperfusion injury, neutrophilic infiltration of the myocardium is mediated by adhesion molecule expression on activated coronary endothelium. Nitric oxide inhibits neutrophil adhesion to endothelium in vitro by blocking the nuclear factor (NF)-kappaB-dependent transcription of adhesion molecules. We investigated whether intraoperative gene delivery of endothelial nitric oxide synthase (eNOS) into donor hearts before transplantation would have a similar effect on an entire organ.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2753-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11390348-Animals,
pubmed-meshheading:11390348-Apoptosis,
pubmed-meshheading:11390348-Endothelium, Vascular,
pubmed-meshheading:11390348-Gene Transfer Techniques,
pubmed-meshheading:11390348-Graft Survival,
pubmed-meshheading:11390348-Heart Transplantation,
pubmed-meshheading:11390348-In Situ Nick-End Labeling,
pubmed-meshheading:11390348-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11390348-Leukocytes,
pubmed-meshheading:11390348-Liposomes,
pubmed-meshheading:11390348-Myocardium,
pubmed-meshheading:11390348-NF-kappa B,
pubmed-meshheading:11390348-Nitric Oxide,
pubmed-meshheading:11390348-Nitric Oxide Synthase,
pubmed-meshheading:11390348-Nitric Oxide Synthase Type III,
pubmed-meshheading:11390348-Rabbits,
pubmed-meshheading:11390348-Time Factors,
pubmed-meshheading:11390348-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2001
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pubmed:articleTitle |
Liposome-mediated gene transfection of endothelial nitric oxide synthase reduces endothelial activation and leukocyte infiltration in transplanted hearts.
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pubmed:affiliation |
University of Washington, Seattle, WA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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