Linked Life Data

11359365

Source:http://linkedlifedata.com/resource/pubmed/id/11359365

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-21
pubmed:abstractText
The microtubule network is in a dynamic equilibrium between free and polymerized tubulin, with depolymerization resulting in increased cellular contractility (1-4). Originally, microtubule depolymerization was thought to facilitate contractile responses via the release of an internal, mechanical opposition to contraction. However, recent evidence suggests that depolymerization may also lead to the enhanced activity of various intracellular signaling proteins. The precise signaling pathway by which microtubule depolymerization facilitates vascular smooth muscle contraction is unknown. In non-vascular cells, depolymerization initiates stress fiber formation via increased activity of the small G-protein, RhoA (5-7). The role of this signaling candidate in a calcium-sensitizing contractile pathway is well established. We and others have found it tempting to speculate that RhoA mediates a contractile pathway enhanced by microtubule depolymerization. We further hypothesize the involvement of microtubule depolymerization (via RhoA and Rho-kinase) in the regulation of vascular smooth muscle contraction, with evidence of potential augmentations of this pathway contributing to the increased vasoconstrictor sensitivity seen in various hypertensive animal models.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0306-9877
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Harcourt Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Microtubule depolymerization facilitates contraction of vascular smooth muscle via increased activation of RhoA/Rho-kinase.
pubmed:affiliation
Department of Physiology, University of Michigan, Ann Arbor, MI 48019, USA. kanchanc@umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.