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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-5-16
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pubmed:abstractText |
Recent studies have suggested that the central nervous system is responsible for activation of sympathetic nerve activity (SNA) and the renin-angiotensin system in heart failure (HF). The aim of this study was to determine whether activation of the renin-angiotensin system within the nucleus of the solitary tract (NTS) plays a role in enhanced SNA in HF. High-output HF was induced by an aortocaval (A-V) shunt with some modifications in the rat. These rats exhibited a left ventricular dilatation and hemodynamic signs of high-output HF. Urinary catecholamine excretion and maximal renal SNA (RSNA) were greater in the A-V shunted rats than in the control rats. Microinjection of an angiotensin II type 1-receptor antagonist, CV11974, into the NTS was performed. The arterial pressure and RSNA were reduced by CV11974 to a greater degree in the A-V shunted rats than in the control rats. The expression of angiotensin-converting enzyme mRNA in the medulla was greater in the A-V shunted rats than in the control rats. These results suggest that activation of the renin-angiotensin system within the NTS contributes to an enhanced SNA in this model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0363-6119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R1665-73
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11353669-Angiotensin II,
pubmed-meshheading:11353669-Animals,
pubmed-meshheading:11353669-Antihypertensive Agents,
pubmed-meshheading:11353669-Aorta,
pubmed-meshheading:11353669-Arteriovenous Shunt, Surgical,
pubmed-meshheading:11353669-Benzimidazoles,
pubmed-meshheading:11353669-Blood Pressure,
pubmed-meshheading:11353669-Echocardiography,
pubmed-meshheading:11353669-Heart Rate,
pubmed-meshheading:11353669-Hemodynamics,
pubmed-meshheading:11353669-Imidazoles,
pubmed-meshheading:11353669-Kidney,
pubmed-meshheading:11353669-Male,
pubmed-meshheading:11353669-Microinjections,
pubmed-meshheading:11353669-Pyridines,
pubmed-meshheading:11353669-Rats,
pubmed-meshheading:11353669-Rats, Inbred WKY,
pubmed-meshheading:11353669-Solitary Nucleus,
pubmed-meshheading:11353669-Sympathetic Nervous System,
pubmed-meshheading:11353669-Tetrazoles,
pubmed-meshheading:11353669-Venae Cavae
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pubmed:year |
2001
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pubmed:articleTitle |
Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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