|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0021665,
umls-concept:C0181904,
umls-concept:C0205234,
umls-concept:C0205374,
umls-concept:C0205421,
umls-concept:C0596972,
umls-concept:C0728873,
umls-concept:C0815279,
umls-concept:C0917798,
umls-concept:C1517004,
umls-concept:C1521743,
umls-concept:C1704646
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-9-6
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|
pubmed:abstractText |
Insulin-like growth factor (IGF) treatment has been shown to have trophic and neuroprotective effects in vitro and in vivo in different lesion models. IGF-I has potent neuroprotective effects after hypoxic-ischemic injury and global ischemia. The role of IGF-I in focal cerebral ischemia is only partially understood. Therefore, in the present study, we evaluated, by applying MRI monitoring, whether a clinically relevant systemic administration of IGF-I can achieve a long-lasting neuroprotective effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1226-33
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:11340238-Animals,
pubmed-meshheading:11340238-Blood Flow Velocity,
pubmed-meshheading:11340238-Body Weight,
pubmed-meshheading:11340238-Cerebrovascular Circulation,
pubmed-meshheading:11340238-Disease Models, Animal,
pubmed-meshheading:11340238-Drug Administration Schedule,
pubmed-meshheading:11340238-Infarction, Middle Cerebral Artery,
pubmed-meshheading:11340238-Infusion Pumps, Implantable,
pubmed-meshheading:11340238-Injections, Intraventricular,
pubmed-meshheading:11340238-Injections, Subcutaneous,
pubmed-meshheading:11340238-Insulin-Like Growth Factor I,
pubmed-meshheading:11340238-Ischemic Attack, Transient,
pubmed-meshheading:11340238-Magnetic Resonance Imaging,
pubmed-meshheading:11340238-Male,
pubmed-meshheading:11340238-Neurologic Examination,
pubmed-meshheading:11340238-Neuroprotective Agents,
pubmed-meshheading:11340238-Rats,
pubmed-meshheading:11340238-Rats, Wistar,
pubmed-meshheading:11340238-Time Factors,
pubmed-meshheading:11340238-Treatment Outcome
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pubmed:year |
2001
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|
pubmed:articleTitle |
Delayed neuroprotective effect of insulin-like growth factor-i after experimental transient focal cerebral ischemia monitored with mri.
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pubmed:affiliation |
Department of Neurology, University of Heidelberg, Heidelberg, Germany. wolf_schaebitz@med.uni-heidelberg.de
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pubmed:publicationType |
Journal Article
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