Linked Life Data

11304646

Source:http://linkedlifedata.com/resource/pubmed/id/11304646

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-4-17
pubmed:abstractText
Homocysteine is an amino acid and a product of methionine metabolism that is metabolized through two different enzymatic pathways: transsulfuration and remethylation. Vitamin B6 is important in homocysteine transsulfuration, whereas folate and vitamin B12 play significant roles in homocysteine remethylation. The hyperhomocysteinemia offers an explanation for observations on human arteriosclerosis that are difficult to explain by the cholesterol/fat approach. However, hyperhomocysteinemia can influence cognitive functions in the elderly. The causes of hyperhomocysteinemia are inherited and acquired. The treatment of hyperhomocysteinemia varies with underlying cause; generally, vitamin supplementation (with folic acid and vitamins B6 and B12) is effective in reducing homocysteine concentrations. Also, specific recommendations, food fortification with folic acid, and preventive strategies in European countries (as in United States) are necessary to decrease cardiovascular morbidity and mortality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1075-2765
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-7
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Homocysteine and arteriosclerosis: established risk factor or new illusion?
pubmed:affiliation
Institute of Physiology and Dedinje Cardiovascular Institute, University School of Medicine, Belgrade, Yugoslavia.
pubmed:publicationType
Journal Article, Review