Linked Life Data

11303593

Source:http://linkedlifedata.com/resource/pubmed/id/11303593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-4-16
pubmed:abstractText
The ratio of urinary 6beta-hydroxycortisol:cortisol is a measure of the activity of cytochrome p450 3A4 (CYP3A4). CYP3A4 catalyzes the formation of the genotoxic estrogen, 16alpha-hydroxyestrone. It is also involved in the activation of many other mammary carcinogens, such as the polycyclic aromatic hydrocarbons and heterocyclic amines. We evaluated the association between urinary cortisol ratios and breast cancer risk in a subgroup of women who participated in a population-based case-control study in Shanghai. Overnight urine samples from 246 case-control pairs were assayed for 6beta-hydroxycortisol (6beta-OHC) to cortisol. The urine samples from all of the breast cancer patients were collected before any chemotherapy or radiotherapy. In-person interviews were conducted to obtain comprehensive information on dietary habits, reproductive history, and other lifestyle factors. The median levels of 6beta-OHC:cortisol ratios were 2.61 in cases and 2.16 in controls, a 20.8% difference (P < 0.001). The case-control difference was larger in women over 45 years of age (31.3% difference; P < 0.001) than younger women (6.0%; P = 0.45). After adjusting for confounding variables, the risks of breast cancer were increased from 1.0 (reference) to 1.6 [95% confidence interval (CI), 0.9-3.1], 2.2 (95% CI, 1.1-4.2), and 3.7 (95% CI, 1.9-7.4; P for trend, <0.001) with increasing levels of 6beta-OHC:cortisol ratios. The positive association was more pronounced among older women (>45 years) than among younger women (< or = 45 years). The adjusted odds ratios associated with the highest cortisol ratio were 6.0 (95%CI, 2.2-16.1) among older women and 2.2 (95%CI, 0.8-6.1) among younger women. The association of the 6beta-OHC:cortisol ratio was stronger among older women who had a high body mass index, late age at menopause, and early age at menarche (factors related to high endogenous estrogen exposure) than those who did not have these factors. These findings are consistent with the role of CYP3A4 in estrogen and carcinogen metabolism and suggest that high CYP3A4 activity may be a risk factor for breast cancer risk.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11303593-Adult, pubmed-meshheading:11303593-Age Distribution, pubmed-meshheading:11303593-Breast Neoplasms, pubmed-meshheading:11303593-Case-Control Studies, pubmed-meshheading:11303593-China, pubmed-meshheading:11303593-Cohort Studies, pubmed-meshheading:11303593-Confidence Intervals, pubmed-meshheading:11303593-Cytochrome P-450 CYP3A, pubmed-meshheading:11303593-Cytochrome P-450 Enzyme System, pubmed-meshheading:11303593-Female, pubmed-meshheading:11303593-Humans, pubmed-meshheading:11303593-Hydrocortisone, pubmed-meshheading:11303593-Incidence, pubmed-meshheading:11303593-Middle Aged, pubmed-meshheading:11303593-Mixed Function Oxygenases, pubmed-meshheading:11303593-Odds Ratio, pubmed-meshheading:11303593-Probability, pubmed-meshheading:11303593-Reference Values, pubmed-meshheading:11303593-Risk Assessment, pubmed-meshheading:11303593-Risk Factors, pubmed-meshheading:11303593-Sensitivity and Specificity, pubmed-meshheading:11303593-Tumor Markers, Biological
pubmed:year
2001
pubmed:articleTitle
Epidemiological study of urinary 6beta-hydroxycortisol to cortisol ratios and breast cancer risk.
pubmed:affiliation
Vanderbilt Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232-8300, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.