Linked Life Data

11282215

Source:http://linkedlifedata.com/resource/pubmed/id/11282215

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-4-3
pubmed:abstractText
Electrical field stimulation (4 Hz, 0.2 ms, 70 V supramaximal voltage, 10 s duration) produced contraction of perfused rabbit central ear arteries, and this contraction was reduced by incubation with insulin (0.6--200 mU/ml). This inhibitory effect of insulin was not significantly modified by removing the endothelium, or by treatment with N(W)-nitro-L-arginine (L-NA, 10(-4) M), meclofenamate (10(-5) M), ouabain (10(-6) M), or cocaine (10(-5) M). Insulin (200 mU/ml) did not modify the vascular contraction due to exogenous norepinephrine (10(-8)--10(-4) M) nor the relaxation due to acetylcholine (10(-8)--10(-4) M). This suggests that insulin may reduce vascular contraction by sympathetic stimulation, and this effect is not dependent on endothelial nitric oxide, prostanoids, or Na(+)--K(+) pump activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Insulin effects on the sympathetic contraction of rabbit ear arteries.
pubmed:affiliation
Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo, 2, 28029 Madrid, Spain. angeluis.villalon@uam.es
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't