rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1975-7-3
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pubmed:abstractText |
Septicaemia still presents a major diagnostic and therapeutic challenge to the clinician. Most cases are hospital-acquiredand the reasons for their increasing prevalence are discussed, with reference to predisposing factors and opportunistic infections. The pathology and bacteriology of proven cases (positive blood cultures) in 1974 in a modern children's and maternity hospital complex are presented. Gram-positive and Gram-negative varieties are compared and the molecular biology and mechansims of endo- and exotoxaemia described. Successful therapy demands correct choice of antibiotic and the development of shock requires skilled supportive measures. For the former a rational scheme is outlined and a plea is made for collection of data for this purpose. Polypharmacy is deprecated and either an aminoglycoside or a cephalosporin forms the mainstay of therapy. The emergence of Bacteroids sp. in cases of abdominal and puerperal sepsis necessitates addition of a lincomycin or metronidazole. Superinfection with systemic candidiasis requires 5-fluorocytosine.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0036-9330
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
85-91
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1124391-Cefazolin,
pubmed-meshheading:1124391-Cephaloridine,
pubmed-meshheading:1124391-Cephalothin,
pubmed-meshheading:1124391-Cephradine,
pubmed-meshheading:1124391-Clindamycin,
pubmed-meshheading:1124391-Drug Resistance, Microbial,
pubmed-meshheading:1124391-Flucytosine,
pubmed-meshheading:1124391-Gentamicins,
pubmed-meshheading:1124391-Humans,
pubmed-meshheading:1124391-Lincomycin,
pubmed-meshheading:1124391-Metronidazole,
pubmed-meshheading:1124391-Sepsis,
pubmed-meshheading:1124391-Shock, Septic,
pubmed-meshheading:1124391-Tobramycin
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pubmed:year |
1975
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pubmed:articleTitle |
Septicaemia.
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pubmed:publicationType |
Journal Article
|