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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
In this study we evaluate the antifibrotic properties of PG-490-88, a water-soluble derivative of triptolide. Triptolide is an oxygenated diterpene that is derived from a traditional Chinese herb that has potent immunosuppressive and antitumor activity. We used the intratracheal bleomycin mouse model and found that PG490-88 inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. PG490-88 also markedly reduced the number of myofibroblasts in the bleomycin treatment group. An enzyme-linked immunosorbent assay of transforming growth factor (TGF)-beta in the bronchoalveolar lavage fluid showed a significant decrease in TGF-beta in the PG490-88-treated groups compared to the bleomycin-treated group. Additionally, triptolide blocked bleomycin-induced increase in TGF-beta mRNA in cultured normal human lung fibroblasts. The efficacy of PG490-88 when administered late after bleomycin installation suggests a potential role in the treatment of idiopathic pulmonary fibrosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-10224109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-10224110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-10528036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-1371688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-13786180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-1819894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-1859050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-2221080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-2509153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-2669218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-2751176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-2888109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-3366935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-3456347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-3470308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-5072337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-7513699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-8558449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-8874268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-9029176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-9070193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238047-9657557
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
997-1004
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11238047-Animals,
pubmed-meshheading:11238047-Bleomycin,
pubmed-meshheading:11238047-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:11238047-Cell Survival,
pubmed-meshheading:11238047-Diterpenes,
pubmed-meshheading:11238047-Drugs, Chinese Herbal,
pubmed-meshheading:11238047-Epoxy Compounds,
pubmed-meshheading:11238047-Fibroblasts,
pubmed-meshheading:11238047-Immunosuppressive Agents,
pubmed-meshheading:11238047-Inflammation,
pubmed-meshheading:11238047-Lung,
pubmed-meshheading:11238047-Male,
pubmed-meshheading:11238047-Mice,
pubmed-meshheading:11238047-Mice, Inbred C57BL,
pubmed-meshheading:11238047-Phenanthrenes,
pubmed-meshheading:11238047-Pulmonary Fibrosis,
pubmed-meshheading:11238047-Transcription, Genetic,
pubmed-meshheading:11238047-Transforming Growth Factor beta
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pubmed:year |
2001
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pubmed:articleTitle |
PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.
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pubmed:affiliation |
Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, 300 Pasteur Dr., Stanford, CA 94305-5236, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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