|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0012634,
umls-concept:C0016658,
umls-concept:C0023779,
umls-concept:C0085542,
umls-concept:C0175668,
umls-concept:C0376249,
umls-concept:C0443252,
umls-concept:C0475224,
umls-concept:C0936012,
umls-concept:C1280500,
umls-concept:C1948041,
umls-concept:C2587213,
umls-concept:C2603343
|
|
pubmed:issue |
9255
|
|
pubmed:dateCreated |
2001-3-2
|
|
pubmed:abstractText |
Statins inhibit the same biochemical pathway as aminobisphosphonates, therefore these cholesterol-lowering agents may have a beneficial effect on osteoporosis. This possibility has been supported by the finding that some statins also stimulate bone formation, and by observational studies suggesting that patients using statins have higher bone densities and lower fracture rates than controls. To assess whether statins have clinically significant effects on bone, we studied the frequency of fractures in a large randomised controlled trial of these agents.
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|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
357
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
509-12
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:11229669-Aged,
pubmed-meshheading:11229669-Anticholesteremic Agents,
pubmed-meshheading:11229669-Bone and Bones,
pubmed-meshheading:11229669-Cohort Studies,
pubmed-meshheading:11229669-Coronary Disease,
pubmed-meshheading:11229669-Double-Blind Method,
pubmed-meshheading:11229669-Female,
pubmed-meshheading:11229669-Fractures, Bone,
pubmed-meshheading:11229669-Humans,
pubmed-meshheading:11229669-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:11229669-Male,
pubmed-meshheading:11229669-Osteoporosis,
pubmed-meshheading:11229669-Pravastatin
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease.
|
|
pubmed:affiliation |
Department of Medicine, University of Auckland, New Zealand. i.reid@auckland.ac.nz
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
