Linked Life Data

11223463

Source:http://linkedlifedata.com/resource/pubmed/id/11223463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-3-6
pubmed:abstractText
We examined regional and intracellular distribution of Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaM-KK beta), which activated Ca(2+)/calmodulin-dependent protein kinase I and IV (CaM-K I and IV) immunohistochemically in the central nervous system of the rat by light and electron microscopy. Although most neurons in the brain and spinal cord exhibited the immunoreactivity, no labeled neurons were observed in the globus pallidus or entopeduncular nucleus, and only a small number of neurons showed weak immunoreactivity in the substantia nigra pars reticulata. In general, the immunoreactivity was observed both in the cytoplasm and cellular nucleus, although the immunoreactivity was not found in the cellular nucleus in some large neurons such as in the mesencephalic trigeminal nucleus, lateral vestibular nucleus or gigant cellular reticular formation. As to motoneurons of the cranial nerve nuclei and the anterior horn of the spinal cord, they revealed the immunoreactivity both in the cytoplasm and nucleus. The reaction product appeared as fine granules in the cytoplasm and nucleus under light microscopy. Electron microscopic observations confirmed that the reaction product was localized mainly on the Golgi apparatus or on the nuclear chromatin. Immunolabeling for antibody against CaM-KK beta was discussed with the distribution of CaM-K I, IV and another CaM-KK, CaM-KK alpha, in the central nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-88
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11223463-Animals, pubmed-meshheading:11223463-Brain, pubmed-meshheading:11223463-Calcium-Calmodulin-Dependent Protein Kinase Kinase, pubmed-meshheading:11223463-Calcium-Calmodulin-Dependent Protein Kinase Type 1, pubmed-meshheading:11223463-Calcium-Calmodulin-Dependent Protein Kinase Type 4, pubmed-meshheading:11223463-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:11223463-Cerebellum, pubmed-meshheading:11223463-Diencephalon, pubmed-meshheading:11223463-Immunohistochemistry, pubmed-meshheading:11223463-Mesencephalon, pubmed-meshheading:11223463-Nerve Tissue Proteins, pubmed-meshheading:11223463-Neurons, pubmed-meshheading:11223463-Pons, pubmed-meshheading:11223463-Protein-Serine-Threonine Kinases, pubmed-meshheading:11223463-Rats, pubmed-meshheading:11223463-Telencephalon
pubmed:year
2001
pubmed:articleTitle
Immunohistochemical localization of Ca(2+)/calmodulin-dependent protein kinase kinase beta in the rat central nervous system.
pubmed:affiliation
Section of Neuroanatomy, Graduate School of Medical and Dental Research, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan. yshs.nakamura.ana3@med.tmd.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't