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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2001-1-9
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pubmed:abstractText |
The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing neoadjuvant chemotherapy followed by loco-regional treatment to the same loco-regional treatment without chemotherapy. The loco-regional treatment consisted either of surgery plus plus radiotherapy or of radiotherapy alone. Three cycles of chemotherapy consisting of Cisplatin (100 mg/m2) on day 1 followed by a 24-hour i.v. infusion of fluorouracil (1000 mg/m2/day) for 5 days were delivered every 21 days. 2-3 weeks after the end of chemotherapy, local treatment was performed. The trial was conducted by the Groupe d'Etude des Tumeurs de la Tête Et du Cou (GETTEC). A total of 318 patients were enrolled in the study between 1986 and 1992. Overall survival was significantly better (P = 0.03) in the neoadjuvant chemotherapy group than in the control group, with a median survival of 5.1 years versus 3.3 years in the no chemotherapy group. The effect of neoadjuvant chemotherapy on event-free survival was smaller and of borderline significance (P = 0.11). Stratification of the results on the type of local treatment, surgery plus radiotherapy or radiotherapy alone, did not reveal any heterogeneity in the effect of chemotherapy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:Coche-DequeantBB,
pubmed-author:De RaucourtDD,
pubmed-author:DomengeCC,
pubmed-author:French Groupe d'Etude des Tumeurs de la Tête et du Cou (GETTEC),
pubmed-author:HillCC,
pubmed-author:LefebvreJ LJL,
pubmed-author:LuboinskiBB,
pubmed-author:MarandasPP,
pubmed-author:RheinBB,
pubmed-author:Sancho-GarnierHH,
pubmed-author:Stromboni-LuboinskiMM,
pubmed-author:WibaultPP
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1594-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11189100-Adult,
pubmed-meshheading:11189100-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11189100-Carcinoma, Squamous Cell,
pubmed-meshheading:11189100-Chemotherapy, Adjuvant,
pubmed-meshheading:11189100-Cisplatin,
pubmed-meshheading:11189100-Combined Modality Therapy,
pubmed-meshheading:11189100-Disease-Free Survival,
pubmed-meshheading:11189100-Fatigue,
pubmed-meshheading:11189100-Female,
pubmed-meshheading:11189100-Fluorouracil,
pubmed-meshheading:11189100-Humans,
pubmed-meshheading:11189100-Leukopenia,
pubmed-meshheading:11189100-Male,
pubmed-meshheading:11189100-Middle Aged,
pubmed-meshheading:11189100-Nausea,
pubmed-meshheading:11189100-Neoadjuvant Therapy,
pubmed-meshheading:11189100-Oropharyngeal Neoplasms,
pubmed-meshheading:11189100-Proportional Hazards Models,
pubmed-meshheading:11189100-Thrombocytopenia,
pubmed-meshheading:11189100-Treatment Outcome,
pubmed-meshheading:11189100-Vomiting
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pubmed:year |
2000
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pubmed:articleTitle |
Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tête et du Cou (GETTEC).
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pubmed:affiliation |
Département de chirurgie cervico-faciale, Institut Gustave Roussy, Villlejuif, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
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