Linked Life Data

11161563

Source:http://linkedlifedata.com/resource/pubmed/id/11161563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-22
pubmed:abstractText
In the embryonic visual system, EphA receptors are expressed on both temporal and nasal retinal ganglion cell axons. Only the temporal axons, however, are sensitive to the low concentrations of ephrin-A ligands found in the anterior optic tectum. The poor responsiveness of nasal axons to ephrin-A ligands, which allows them to traverse the anterior tectum and reach their targets in the posterior tectum, has been attributed to constitutive activation of the EphA4 receptor expressed in these axons. EphA4 is highly expressed throughout the retina, but is preferentially phosphorylated on tyrosine (activated) in nasal retina. In a screen for EphA4 ligands expressed in chicken embryonic retina, we have identified a novel ephrin, ephrin-A6. Like ephrin-A5, ephrin-A6 has high affinity for EphA4 and activates this receptor in cultured retinal cells. In the embryonic day 8 (E8) chicken visual system, ephrin-A6 is predominantly expressed in the nasal retina and ephrin-A5 in the posterior tectum. Thus, ephrin-A6 has the properties of a ligand that activates the EphA4 receptor in nasal retinal cells. Ephrin-A6 binds with high affinity to several other EphA receptors as well and causes growth cone collapse in retinal explants, demonstrating that it can elicit biological responses in retinal neurons. Ephrin-A6 expression is high at E6 and E8, when retinal axons grow to their tectal targets, and gradually declines at later developmental stages. The asymmetric distribution of ephrin-A6 in retinal cells, and the time course of its expression, suggest that this new ephrin plays a role in the establishment of visual system topography.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
230
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-88
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11161563-Amino Acid Sequence, pubmed-meshheading:11161563-Animals, pubmed-meshheading:11161563-Base Sequence, pubmed-meshheading:11161563-Chick Embryo, pubmed-meshheading:11161563-Cloning, Molecular, pubmed-meshheading:11161563-DNA, Complementary, pubmed-meshheading:11161563-DNA Primers, pubmed-meshheading:11161563-Ephrin-A5, pubmed-meshheading:11161563-Fetal Proteins, pubmed-meshheading:11161563-Gene Expression, pubmed-meshheading:11161563-Ligands, pubmed-meshheading:11161563-Membrane Proteins, pubmed-meshheading:11161563-Molecular Sequence Data, pubmed-meshheading:11161563-Proteins, pubmed-meshheading:11161563-RNA, Messenger, pubmed-meshheading:11161563-Receptor, EphA4, pubmed-meshheading:11161563-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:11161563-Retinal Ganglion Cells, pubmed-meshheading:11161563-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:11161563-Sequence Homology, Amino Acid, pubmed-meshheading:11161563-Superior Colliculi
pubmed:year
2001
pubmed:articleTitle
Ephrin-A6, a new ligand for EphA receptors in the developing visual system.
pubmed:affiliation
The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, California 92037, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.