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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-3
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pubmed:abstractText |
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AtassiGG,
pubmed-author:CaignardD HDH,
pubmed-author:DingJJ,
pubmed-author:LéonceSS,
pubmed-author:LUMM,
pubmed-author:RenardPP,
pubmed-author:ShaoGG,
pubmed-author:WuG SGS,
pubmed-author:WuJ MJM,
pubmed-author:XiaoDD,
pubmed-author:YangW YWY
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11140731-Animals,
pubmed-meshheading:11140731-Antineoplastic Agents,
pubmed-meshheading:11140731-Apoptosis,
pubmed-meshheading:11140731-Artemisinins,
pubmed-meshheading:11140731-Cell Division,
pubmed-meshheading:11140731-G1 Phase,
pubmed-meshheading:11140731-Humans,
pubmed-meshheading:11140731-Inhibitory Concentration 50,
pubmed-meshheading:11140731-Mice,
pubmed-meshheading:11140731-Models, Molecular,
pubmed-meshheading:11140731-Molecular Structure,
pubmed-meshheading:11140731-Sesquiterpenes,
pubmed-meshheading:11140731-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.
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pubmed:affiliation |
Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. yli@mail.shcnc.ac.cn
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pubmed:publicationType |
Journal Article
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