Source:http://linkedlifedata.com/resource/pubmed/id/11101632
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2001-1-11
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| pubmed:abstractText |
The presence of neuronal nitric oxide synthase (nNOS) in two populations of pituitary cells, gonadotrophs (LH) and folliculostellate (FS) cells, suggests that pituitary nitric oxide (NO) is involved in the control of hormone secretion. We have used single and double immunostaining and quantitative procedures to investigate possible gender-related differences in the nNOS expression pattern in the anterior pituitary lobe and its possible alterations in different endocrine situations. Our results reveal a sexual dimorphism in the pattern of nNOS expression. In males, nNOS is mainly found in FS cells, whereas only a few LH cells express nNOS. Conversely, in females, nNOS is mainly found in LH cells. After gonadectomy, paralleling an increase in LH cell size and serum luteinizing hormone (LH) levels, there is nNOS upregulation in LH cells and nNOS downregulation in FS cells. After testoterone replacement, LH cells become nNOS-immunonegative again. In lactating rats, LH cells overexpress nNOS, but LH cell size and serum LH levels are low. This suggests that, depending on its cellular source, pituitary NO can exert either an inhibitory or a stimulatory effect on hormone secretion. When released from FS cells, NO exerts a paracrine inhibitory effect, and when released from gonadotrophs it exerts an autocrine or paracrine stimulatory effect on LH or prolactin secretion, respectively.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0022-1554
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1639-48
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11101632-Animals,
pubmed-meshheading:11101632-Castration,
pubmed-meshheading:11101632-Diestrus,
pubmed-meshheading:11101632-Female,
pubmed-meshheading:11101632-Fluorescent Antibody Technique,
pubmed-meshheading:11101632-Immunohistochemistry,
pubmed-meshheading:11101632-Isoenzymes,
pubmed-meshheading:11101632-Lactation,
pubmed-meshheading:11101632-Luteinizing Hormone,
pubmed-meshheading:11101632-Male,
pubmed-meshheading:11101632-Neurons,
pubmed-meshheading:11101632-Nitric Oxide Synthase,
pubmed-meshheading:11101632-Orchiectomy,
pubmed-meshheading:11101632-Ovariectomy,
pubmed-meshheading:11101632-Pituitary Gland, Anterior,
pubmed-meshheading:11101632-Rats,
pubmed-meshheading:11101632-Rats, Sprague-Dawley,
pubmed-meshheading:11101632-Sex Factors,
pubmed-meshheading:11101632-Testosterone
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Gender differences and the effect of different endocrine situations on the NOS expression pattern in the anterior pituitary gland.
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| pubmed:affiliation |
Departments of Anatomy, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain. tgonhern@ull.es
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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