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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2000-11-30
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pubmed:abstractText |
Several endogenous cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF), are necessary for eliminating Histoplasma capsulatum from tissues. In this study, we explored the efficacy of recombinant murine GM-CSF in the treatment of pulmonary histoplasmosis. This cytokine significantly reduced fungal burden in a dose-dependent manner. Pretreatment did not consistently produce a better result than treatment started after infection. The biological effectiveness of GM-CSF was not associated with modulation of lung cytokine production or alteration in lung inflammation, but it directly activated a nonadherent lung cell population to exert anti-Histoplasma activity. GM-CSF improved survival of T-cell-depleted mice exposed to H. capsulatum. When combined with a suboptimal amount of amphotericin B, GM-CSF enhanced survival of normal or T-cell-depleted mice given a lethal challenge. These results suggest that this cytokine may be useful as an adjunctive treatment for histoplasmosis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-10201989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-10358191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-10447725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-10528203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-1375975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-1398972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-1639513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-1890560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-1948028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-2968320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-3025331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-3083507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-3119762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-3141506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-3489188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-7492274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-7608555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-7697258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-7883967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-8144930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-8158029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-8188361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-8757857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9086148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9199420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9227523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9233638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9234807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9529070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9547342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9548493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9570555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9596739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083636-9637524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3328-36
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11083636-Amphotericin B,
pubmed-meshheading:11083636-Animals,
pubmed-meshheading:11083636-Cytokines,
pubmed-meshheading:11083636-Dose-Response Relationship, Drug,
pubmed-meshheading:11083636-Drug Interactions,
pubmed-meshheading:11083636-Flow Cytometry,
pubmed-meshheading:11083636-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:11083636-Histoplasma,
pubmed-meshheading:11083636-Histoplasmosis,
pubmed-meshheading:11083636-Immunocompetence,
pubmed-meshheading:11083636-Immunocompromised Host,
pubmed-meshheading:11083636-Leukocytes,
pubmed-meshheading:11083636-Lung,
pubmed-meshheading:11083636-Male,
pubmed-meshheading:11083636-Mice,
pubmed-meshheading:11083636-Mice, Inbred C57BL,
pubmed-meshheading:11083636-Recombinant Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice.
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pubmed:affiliation |
Division of Infectious Diseases, University of Cincinnati College of Medicine and the Veterans Affairs Hospital, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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