rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-12-15
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pubmed:abstractText |
In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Checkpoint kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...,
http://linkedlifedata.com/resource/pubmed/chemical/checkpoint kinase 2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0955-0674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-704
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:11063934-Animals,
pubmed-meshheading:11063934-Cell Cycle,
pubmed-meshheading:11063934-Cell Cycle Proteins,
pubmed-meshheading:11063934-Cell Transformation, Neoplastic,
pubmed-meshheading:11063934-DNA Repair,
pubmed-meshheading:11063934-DNA Replication,
pubmed-meshheading:11063934-DNA-Binding Proteins,
pubmed-meshheading:11063934-Drosophila,
pubmed-meshheading:11063934-Embryo, Mammalian,
pubmed-meshheading:11063934-Embryo, Nonmammalian,
pubmed-meshheading:11063934-Genes, cdc,
pubmed-meshheading:11063934-Genetic Predisposition to Disease,
pubmed-meshheading:11063934-Mice,
pubmed-meshheading:11063934-Protein Kinases,
pubmed-meshheading:11063934-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11063934-Tumor Suppressor Protein p53,
pubmed-meshheading:11063934-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Cell-cycle checkpoint kinases: checking in on the cell cycle.
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pubmed:affiliation |
Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854-5635, USA. walworna@umdnj.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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