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pubmed:abstractText |
Glomerular mesangial cell (MC) proliferation, hypertrophy, and abnormal matrix remodeling characterized by increased expression of fibronectin, laminin and collagen type IV, and neoexpression of collagen I and III are the main biological features of progressive glomerulonephritis (GN). Especially, persistent pathological matrix remodeling may lead to glomerular scar formation (glomerular scarring). We reported recently that alpha1beta1 integrin, a major collagen receptor for MCs, may be a potential adhesion molecule for MC-mediated pathological collagen matrix remodeling in GN.
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pubmed:affiliation |
Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan, and Institute für Molekularbiologie und Biochemi, Freie Universitat Berlin, Berlin-Dahlem, Germany. kagami@medclin.clin.med.tokushima-u.ac.jp
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