| pubmed-article:10969847 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0202098 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0084070 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:10969847 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:10969847 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10969847 | pubmed:dateCreated | 2000-9-25 | lld:pubmed |
| pubmed-article:10969847 | pubmed:abstractText | We studied whether there is an association between the single nucleotide polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syndrome in case-control and intrafamily association studies in 922 subjects from Finland and Sweden. No difference was observed in the Q allele frequency between control subjects and type 2 diabetic subjects (12.9 vs. 15.1%). The QK genotype was associated with higher fasting plasma glucose (FPG) concentrations than the KK genotype in type 2 diabetic patients (P <0.001) and their relatives (P <0.05). A permutation test of siblings discordant for the QK and KK genotypes also showed that the nondiabetic siblings with the QK genotype had higher FPG (6.1 +/- 2.0 vs. 5.4 +/- 0.6 mmo/l, P <0.001) and fasting insulin (7.0 +/- 3.6 vs. 4.8 +/- 2.6 mU/l, P <0.05) concentrations than the carriers of the KK genotype. In addition, diabetic siblings with the QK genotype had higher systolic blood pressure (147.0 +/- 18.0 vs. 140.0 +/- 18.7 mmHg, P <0.05) and higher fasting (9.9 +/- 3.0 vs. 8.8 +/- 2.8 mmol/l, P <0.05) and 2-h plasma glucose (17.3 +/- 8.5 vs. 12.9 +/- 4.2 mmol/l, P < 0.05) concentrations than the diabetic carriers of the KK genotype. The present study shows that, although the Q allele of the human glycoprotein PC-1 gene is associated with surrogate measures of insulin resistance, it may not be enough to increase the susceptibility to type 2 diabetes. | lld:pubmed |
| pubmed-article:10969847 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10969847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10969847 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10969847 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10969847 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10969847 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:GroopL CLC | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:LindholmEE | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:FrittittaLL | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:PizzutiAA | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:TrischittaVV | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:GuH FHF | lld:pubmed |
| pubmed-article:10969847 | pubmed:author | pubmed-author:AlmgrenPP | lld:pubmed |
| pubmed-article:10969847 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10969847 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:10969847 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10969847 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10969847 | pubmed:pagination | 1601-3 | lld:pubmed |
| pubmed-article:10969847 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10969847 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10969847 | pubmed:articleTitle | Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. | lld:pubmed |
| pubmed-article:10969847 | pubmed:affiliation | Department of Endocrinology, Lund University, Malmö University Hospital, Sweden. harvest.gu@endo.mas.lu.se | lld:pubmed |
| pubmed-article:10969847 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10969847 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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