Source:http://linkedlifedata.com/resource/pubmed/id/10969847
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2000-9-25
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| pubmed:abstractText |
We studied whether there is an association between the single nucleotide polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syndrome in case-control and intrafamily association studies in 922 subjects from Finland and Sweden. No difference was observed in the Q allele frequency between control subjects and type 2 diabetic subjects (12.9 vs. 15.1%). The QK genotype was associated with higher fasting plasma glucose (FPG) concentrations than the KK genotype in type 2 diabetic patients (P <0.001) and their relatives (P <0.05). A permutation test of siblings discordant for the QK and KK genotypes also showed that the nondiabetic siblings with the QK genotype had higher FPG (6.1 +/- 2.0 vs. 5.4 +/- 0.6 mmo/l, P <0.001) and fasting insulin (7.0 +/- 3.6 vs. 4.8 +/- 2.6 mU/l, P <0.05) concentrations than the carriers of the KK genotype. In addition, diabetic siblings with the QK genotype had higher systolic blood pressure (147.0 +/- 18.0 vs. 140.0 +/- 18.7 mmHg, P <0.05) and higher fasting (9.9 +/- 3.0 vs. 8.8 +/- 2.8 mmol/l, P <0.05) and 2-h plasma glucose (17.3 +/- 8.5 vs. 12.9 +/- 4.2 mmol/l, P < 0.05) concentrations than the diabetic carriers of the KK genotype. The present study shows that, although the Q allele of the human glycoprotein PC-1 gene is associated with surrogate measures of insulin resistance, it may not be enough to increase the susceptibility to type 2 diabetes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Diester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrophosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/ectonucleotide pyrophosphatase...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
49
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1601-3
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10969847-Adult,
pubmed-meshheading:10969847-Aged,
pubmed-meshheading:10969847-Alleles,
pubmed-meshheading:10969847-Blood Glucose,
pubmed-meshheading:10969847-Blood Pressure,
pubmed-meshheading:10969847-Case-Control Studies,
pubmed-meshheading:10969847-Diabetes Mellitus, Type 2,
pubmed-meshheading:10969847-Female,
pubmed-meshheading:10969847-Finland,
pubmed-meshheading:10969847-Gene Frequency,
pubmed-meshheading:10969847-Genetic Predisposition to Disease,
pubmed-meshheading:10969847-Genotype,
pubmed-meshheading:10969847-Humans,
pubmed-meshheading:10969847-Hyperglycemia,
pubmed-meshheading:10969847-Insulin,
pubmed-meshheading:10969847-Male,
pubmed-meshheading:10969847-Membrane Glycoproteins,
pubmed-meshheading:10969847-Middle Aged,
pubmed-meshheading:10969847-Nuclear Family,
pubmed-meshheading:10969847-Phosphoric Diester Hydrolases,
pubmed-meshheading:10969847-Pyrophosphatases,
pubmed-meshheading:10969847-Reference Values,
pubmed-meshheading:10969847-Sweden
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| pubmed:year |
2000
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| pubmed:articleTitle |
Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis.
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| pubmed:affiliation |
Department of Endocrinology, Lund University, Malmö University Hospital, Sweden. harvest.gu@endo.mas.lu.se
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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