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rdf:type |
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lifeskim:mentions |
umls-concept:C0010674,
umls-concept:C0019904,
umls-concept:C0021853,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0037047,
umls-concept:C0040300,
umls-concept:C0041427,
umls-concept:C0239307,
umls-concept:C0596019,
umls-concept:C1513822,
umls-concept:C1609982,
umls-concept:C1880171,
umls-concept:C2603343
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-3
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pubmed:abstractText |
Cholinergic stimulation of chloride secretion is impaired in the intestines of patients with cystic fibrosis (CF). However, intestinal chloride secretion has been observed in patients with mild CF mutations. The aim of this study was to investigate residual Cl(-) secretion in the intestine of DeltaF508 homozygous CF patients, and examine the contribution of cystic fibrosis transmembrane conductance regulator (CFTR) and alternative Cl(-) conductances. Twins and siblings with identical CFTR genotypes were investigated to determine the impact of factors other than CFTR on chloride secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:BallmannMM,
pubmed-author:BijmanJJ,
pubmed-author:BronsveldII,
pubmed-author:BuscheRR,
pubmed-author:De JongeH RHR,
pubmed-author:GreipelJJ,
pubmed-author:HalleyD JDJ,
pubmed-author:HundrieserJJ,
pubmed-author:LaabsUU,
pubmed-author:MekusFF,
pubmed-author:TümmlerBB,
pubmed-author:VeezeH JHJ
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-40
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10889152-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid,
pubmed-meshheading:10889152-Adolescent,
pubmed-meshheading:10889152-Adult,
pubmed-meshheading:10889152-Child,
pubmed-meshheading:10889152-Child, Preschool,
pubmed-meshheading:10889152-Chlorides,
pubmed-meshheading:10889152-Cyclic AMP,
pubmed-meshheading:10889152-Cystic Fibrosis,
pubmed-meshheading:10889152-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:10889152-Diseases in Twins,
pubmed-meshheading:10889152-Electrophysiology,
pubmed-meshheading:10889152-Female,
pubmed-meshheading:10889152-Genotype,
pubmed-meshheading:10889152-Homozygote,
pubmed-meshheading:10889152-Humans,
pubmed-meshheading:10889152-Male,
pubmed-meshheading:10889152-Mutation,
pubmed-meshheading:10889152-Rectum,
pubmed-meshheading:10889152-Reference Values,
pubmed-meshheading:10889152-Twins, Dizygotic,
pubmed-meshheading:10889152-Twins, Monozygotic
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pubmed:year |
2000
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pubmed:articleTitle |
Residual chloride secretion in intestinal tissue of deltaF508 homozygous twins and siblings with cystic fibrosis. The European CF Twin and Sibling Study Consortium.
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pubmed:affiliation |
Department of Pediatrics, Sophia Children's Hospital, Rotterdam, The Netherlands. bronsvel@worldonline.nl
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pubmed:publicationType |
Journal Article
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