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rdf:type |
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lifeskim:mentions |
umls-concept:C0021755,
umls-concept:C0086597,
umls-concept:C0086982,
umls-concept:C0205314,
umls-concept:C0379816,
umls-concept:C0530129,
umls-concept:C0679622,
umls-concept:C1135629,
umls-concept:C1336666,
umls-concept:C1417830,
umls-concept:C1424725,
umls-concept:C1879547
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pubmed:issue |
4
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pubmed:dateCreated |
2000-7-17
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pubmed:databankReference |
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pubmed:abstractText |
The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1 stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-58
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:10882101-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10882101-Amino Acid Sequence,
pubmed-meshheading:10882101-Biological Transport,
pubmed-meshheading:10882101-Carrier Proteins,
pubmed-meshheading:10882101-Cell Membrane,
pubmed-meshheading:10882101-Cloning, Molecular,
pubmed-meshheading:10882101-Cytosol,
pubmed-meshheading:10882101-Enzyme Activation,
pubmed-meshheading:10882101-Gene Library,
pubmed-meshheading:10882101-Humans,
pubmed-meshheading:10882101-Interleukin-1,
pubmed-meshheading:10882101-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10882101-MAP Kinase Kinase Kinases,
pubmed-meshheading:10882101-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10882101-Models, Biological,
pubmed-meshheading:10882101-Molecular Sequence Data,
pubmed-meshheading:10882101-NF-kappa B,
pubmed-meshheading:10882101-Protein Binding,
pubmed-meshheading:10882101-Proteins,
pubmed-meshheading:10882101-Signal Transduction,
pubmed-meshheading:10882101-TNF Receptor-Associated Factor 6,
pubmed-meshheading:10882101-Two-Hybrid System Techniques
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pubmed:year |
2000
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pubmed:articleTitle |
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
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pubmed:affiliation |
Department of Molecular Biology, Graduate School of Science, Nagoya University and CREST, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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