Linked Life Data

10870897

Source:http://linkedlifedata.com/resource/pubmed/id/10870897

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-11-7
pubmed:abstractText
As more therapies are introduced to treat osteoporosis, precise in vivo methods are needed to monitor response to therapy and to estimate the gains in bone strength that result from treatment. A method for evaluating the strength of the proximal femur was developed and its short term reproducibility, or precision, was determined in vivo. Ten volunteer subjects aged 51-62 years (mean 55.6 years), eight women and two men, were examined using a quantitative computed tomography (QCT) protocol. They were positioned, scanned, repositioned and re-scanned. The QCT images were registered in three-dimensional space, and finite element (FE) models were generated and processed to simulate a stance phase load configuration. Stiffness was computed from each FE model, and strength was computed using a regression equation between FE stiffness and fracture load for a small set (n = 6) of experimental specimens. The coefficients of variation (COV) and repeatability (COR= 2.23* 42*COV) were determined. The COV for the FE fracture load computed was 1.85%, and the detectable limit (coefficient of repeatability) for serial measurements was 5.85%. That is, if a change of 5.85% or more in computed FE fracture load is observed, it will be too large to be consistent with measurement variation, but instead can be interpreted as a real change in the strength of the bone. The detectable limit of this method makes it suitable for serial research studies on changes in femoral bone strength in vivo.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-14
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Short term in vivo precision of proximal femoral finite element modeling.
pubmed:affiliation
Diagnostic Radiology, Henry Ford Hospital, Detroit, MI, 48202, USA. dianna@rad,hfh.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't