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pubmed-article:10869261pubmed:abstractTextActivation of Na(+)/H(+) exchange in myocardial ischemia and/or reperfusion leads to calcium overload and myocardial injury. Experimental studies have shown that Na(+)/H(+) exchange inhibitors can attenuate Ca(2+) influx into cardiomyocytes. We therefore performed a multicenter, randomized, placebo-controlled clinical trial to test the hypothesis that inhibition of Na(+)/H(+) exchange limits infarct size and improves myocardial function in patients with acute anterior myocardial infarction (MI) treated with direct PTCA.lld:pubmed
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pubmed-article:10869261pubmed:articleTitleCardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA.lld:pubmed
pubmed-article:10869261pubmed:affiliation2nd Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany. rupprecht@2-med.klinik.uni-mainz.delld:pubmed
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