Linked Life Data

10838220

Source:http://linkedlifedata.com/resource/pubmed/id/10838220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-8-30
pubmed:abstractText
A specialized complex of apical organelles facilitates Plasmodium merozoite invasion into the erythrocyte. Even though the apical organelles are crucial to the invasion process, relatively little is known about how they function or their biosynthesis during asexual replication. MAEBL is an erythrocyte binding protein located in the rhoptries and on the surface of mature merozoites and is expressed at the beginning of schizogony before the first nuclear division. Therefore, we have characterized MAEBL as a marker for the biosynthetic pathway of the rhoptry apical organelle during the final phase of intraerythrocytic development and as a marker for the nascent rhoptry vesicle in the immature schizont. An extensive proliferation of the endoplasmic reticulum occurred at the onset of schizogony and was seen as a complex but transient tubule array near the parasite surface. Both the rhoptry protein MAEBL and surface protein MSP-1 appeared to be present in this tubular reticular network together with endoplasmic reticulum markers. MAEBL then transits through Golgi bodies positioned near the parasite plasma membrane, directly adjacent to the network. Rhoptry organelle precursors are seen at the three to four nuclei stage of schizont development, remaining near the plasma membrane throughout schizogony. These studies constitute the first direct evidence that proteins of the rhoptry organelles transit through compartments of the 'classical' secretory pathway.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0166-6851
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-85
pubmed:dateRevised
2011-10-3
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Spatial and temporal dynamics of the secretory pathway during differentiation of the Plasmodium yoelii schizont.
pubmed:affiliation
Department of Biological Sciences, University of Notre Dame, 46556, Notre Dame, IN, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't