Linked Life Data

10805115

Source:http://linkedlifedata.com/resource/pubmed/id/10805115

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-8-15
pubmed:abstractText
Viability studies are often performed in patients receiving beta-blocking agents. However, the intake of beta-blocking agents could influence the identification of viable myocardium when low-dose dobutamine is used to demonstrate inotropic reserve. The aim of this study was to quantify the effect of beta-blockade on global and regional left ventricular function in healthy volunteers using low-dose dobutamine gated single-photon emission tomographic (SPET) myocardial perfusion scintigraphy. Ten subjects were studied once "on" and once "off" beta-blocker therapy (metoprolol succinate, 100 mg day(-1)). On each occasion four consecutive gated SPET acquisitions (of 7 min duration) were recorded after injection of 925 MBq technetium-99m tetrofosmin on a triple-headed camera equipped with focussing (Cardiofocal) collimators. Acquisitions were made at rest (baseline 1 and 2) and 5 min after the beginning of the infusion of 5 and 10 microg kg(-1) min(-1) dobutamine. Wall thickening (WT) was quantified using a method based on circumferential profile analysis. Left ventricular ejection fraction (LVEF) was obtained using the Cedars-Sinai algorithm. Blood pressure (BP) and heart rate (HR) were recorded at the end of each acquisition. At baseline LVEF, WT and systolic BP values under beta-blockade were not significantly different from those obtained in the non-beta-blocked state. The mean HR and diastolic BP at baseline were lower under beta-blockade. Dobutamine administration (at 5 and 10 microg kg(-1) min(-1)) induced a significant increase in WT, LVEF and systolic BP in all subjects both on and off beta-blockade. The increases in WT, LVEF and systolic BP in the beta-blocked state were less pronounced but not significantly different. HR increased significantly at 10 microg kg(-1) min(-1) dobutamine without beta-blocker administration, while no increase in HR was observed in the beta-blocked state. Beta-blocker therapy in healthy subjects attenuates the inotropic and chronotropic myocardial response to low-dose dobutamine. At doses of 5 and 10 microg kg(-1) min(-1) dobutamine, however, significant increases in global and regional left ventricular function can still be measured using consecutive gated SPET myocardial perfusion scintigraphy acquisitions even under beta-blocker therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0340-6997
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-24
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:10805115-Adrenergic beta-Agonists, pubmed-meshheading:10805115-Adrenergic beta-Antagonists, pubmed-meshheading:10805115-Adult, pubmed-meshheading:10805115-Blood Pressure, pubmed-meshheading:10805115-Dobutamine, pubmed-meshheading:10805115-Heart, pubmed-meshheading:10805115-Heart Rate, pubmed-meshheading:10805115-Humans, pubmed-meshheading:10805115-Male, pubmed-meshheading:10805115-Metoprolol, pubmed-meshheading:10805115-Myocardial Contraction, pubmed-meshheading:10805115-Organophosphorus Compounds, pubmed-meshheading:10805115-Organotechnetium Compounds, pubmed-meshheading:10805115-Radiopharmaceuticals, pubmed-meshheading:10805115-Stroke Volume, pubmed-meshheading:10805115-Tomography, Emission-Computed, Single-Photon, pubmed-meshheading:10805115-Ventricular Function, Left
pubmed:year
2000
pubmed:articleTitle
Effect of beta-blockade on low-dose dobutamine-induced changes in left ventricular function in healthy volunteers: assessment by gated SPET myocardial perfusion scintigraphy.
pubmed:affiliation
Division of Nuclear Medicine, University Hospital, Free University of Brussels (AZ VUB), Belgium. nucgeth@az.vub.ac.be
pubmed:publicationType
Journal Article