Linked Life Data

10750059

Source:http://linkedlifedata.com/resource/pubmed/id/10750059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-6-13
pubmed:abstractText
Analyses of dose response studies should separate the question of the existence of a dose response relationship from questions of functional form and finding the optimal dose. A well-chosen contrast among the estimated effects of the studied doses can make a powerful test for detecting the existence of a dose response relationship. A contrast-based test attains its greatest power when the pattern of the coefficients has the same shape as the true dose response relationship. However, it loses power when the contrast shape and the true dose response shape are not similar. Thus, a primary test based on a single contrast is often risky. Two (or more) appropriately chosen contrasts can assure sufficient power to justify the cost of a multiplicity adjustment. An example shows the success of a two-contrast procedure in detecting dose response, which had frustrated several standard procedures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0277-6715
pubmed:author
pubmed:copyrightInfo
Copyright 2000 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
913-21
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Detecting dose response with contrasts.
pubmed:affiliation
PRA, International, Lenexa, KS 66219, USA.
pubmed:publicationType
Journal Article