| pubmed-article:10741964 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10741964 | lifeskim:mentions | umls-concept:C0021585 | lld:lifeskim |
| pubmed-article:10741964 | lifeskim:mentions | umls-concept:C0032662 | lld:lifeskim |
| pubmed-article:10741964 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:10741964 | lifeskim:mentions | umls-concept:C1527180 | lld:lifeskim |
| pubmed-article:10741964 | pubmed:issue | 5462 | lld:pubmed |
| pubmed-article:10741964 | pubmed:dateCreated | 2000-4-11 | lld:pubmed |
| pubmed-article:10741964 | pubmed:abstractText | A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non-sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently in Drosophila melanogaster, and we expect these principles to be widely applicable to more economically important organisms. | lld:pubmed |
| pubmed-article:10741964 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10741964 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741964 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10741964 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10741964 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10741964 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10741964 | pubmed:author | pubmed-author:ThomasD DDD | lld:pubmed |
| pubmed-article:10741964 | pubmed:author | pubmed-author:WoodR JRJ | lld:pubmed |
| pubmed-article:10741964 | pubmed:author | pubmed-author:AlpheyL SLS | lld:pubmed |
| pubmed-article:10741964 | pubmed:author | pubmed-author:DonnellyC ACA | lld:pubmed |
| pubmed-article:10741964 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10741964 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:10741964 | pubmed:volume | 287 | lld:pubmed |
| pubmed-article:10741964 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10741964 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10741964 | pubmed:pagination | 2474-6 | lld:pubmed |
| pubmed-article:10741964 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10741964 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10741964 | pubmed:articleTitle | Insect population control using a dominant, repressible, lethal genetic system. | lld:pubmed |
| pubmed-article:10741964 | pubmed:affiliation | Department of Zoology, Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. | lld:pubmed |
| pubmed-article:10741964 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10741964 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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