Linked Life Data

10739880

Source:http://linkedlifedata.com/resource/pubmed/id/10739880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-6-28
pubmed:abstractText
Natural D-nucleosides are no longer the sole basis for designing effective antiviral analogues. Many antivirals with an opposite (L) configuration were reported, with lamivudine being the most notable example. In contrast, carbocyclic nucleoside analogues are significantly more enantioselective, and enantiomers with a configuration corresponding to D-nucleosides are usually favored. In the series of acyclic nucleoside analogues, the antiviral potency resides in a single enantiomer. Allenic analogues with an axial dissymmetry are R-enantioselective, in contrast to structurally similar methylenecyclopropanes, where the enantioselectivity strongly depends on the type of virus. Enantioselectivity of acyclic nucleotide analogues exhibits a more complex pattern. The overall enantioselectivity of the antiviral effects is determined by responses of activating (phosphorylating) enzymes, as well as target DNA polymerases (reverse transcriptase), toward enantiomers of active analogues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0163-7258
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-66
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Enantioselectivity of the antiviral effects of nucleoside analogues.
pubmed:affiliation
Department of Chemistry, Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E. Warren Avenue, Detroit, MI, USA. zemlicka@kci.wayne.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review