Linked Life Data

10716255

Source:http://linkedlifedata.com/resource/pubmed/id/10716255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-5-8
pubmed:abstractText
We studied recovery-induced changes in the responsiveness of the primary somatosensory cortex in stroke patients with sensory and/or motor symptoms. Somatosensory evoked magnetic fields, in response to median nerve stimulation, were recorded in 14 patients with their first symptomatic unilateral stroke 1 to 15 days from the first symptoms and again 2 to 3 months later. Neuronal activity at the contralateral primary somatosensory cortex was modeled with equivalent current dipoles at the peak latencies of the first two cortical deflections at about 20 msec (N1m) and at 28 to 91 msec (P1m). Twenty-three age-matched healthy volunteers, 9 of whom were tested also in serial recordings, served as control subjects. At follow-up, 6 patients showed a significant increase of P1m amplitude, whereas N1m increased only in 1. Clinical improvement of two-point discrimination ability, but not of other basic somatosensory skills, was significantly correlated with the increase of P1m. We conclude that the recovery of discriminative touch after stroke is paralleled by the growth of the P1m somatosensory evoked magnetic field deflection, and we propose that this may reflect re-establishment of lateral inhibitory functions at the primary somatosensory cortex.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0364-5134
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Specific changes in somatosensory evoked magnetic fields during recovery from sensorimotor stroke.
pubmed:affiliation
Medical Engineering Centre, and Department of Clinical Neurosciences, Helsinki University Central Hospital, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't