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pubmed-article:10698453pubmed:abstractTextA series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds.lld:pubmed
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pubmed-article:10698453pubmed:articleTitleA novel class of apical sodium co-dependent bile acid transporter inhibitors: the 2,3-disubstituted-4-phenylquinolines.lld:pubmed
pubmed-article:10698453pubmed:affiliationSearle Discovery, Monsanto Life Sciences, St. Louis, MO 63198, USA.lld:pubmed
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