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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-8-23
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pubmed:abstractText |
3H-thymidine autoradiography was used to evaluate DNA-synthesis in carcinoma cells obtained by fine-needle aspiration biopsy from mammary carcinomas. Needle aspirates were analyzed before and after oophorectomy, and before and during treatment with oestrogen or anti-oestrogen (tamoxifen). Tumor regression occurred in 18 patients-in one of four following oophorectomy, in 15 of 38 treated with tamoxifen and in two of three given oestrogen. Seven tumors remained stationary for long periods-up to a year. In 20 cases there was tumor progression. Regression of tumors was preceded by a decrease in the fraction of 3H-thymidine-labeled cells (s-phase cells). The tumors that remained stationary or progressed retained significant levels of 3H-thymidine incorporation. This study thus showed that 3H-thymidine autoradiography can give an early estimate of tumour response to endocrine therapy. Considerable differences were found between the carcinomas in regard to proportions of S-phase cells. Further insight into this parameter may be useful for planning chemotherapy with S-phase specific agents.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Breast Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Cytologic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Gynecologic Surgery,
http://linkedlifedata.com/resource/pubmed/keyword/Histology,
http://linkedlifedata.com/resource/pubmed/keyword/Hormone Antagonists--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms,
http://linkedlifedata.com/resource/pubmed/keyword/Ovariectomy--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Surgery,
http://linkedlifedata.com/resource/pubmed/keyword/Tamoxifen--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Treatment,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital Surgery
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0001-5547
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-43
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1065173-Adult,
pubmed-meshheading:1065173-Aged,
pubmed-meshheading:1065173-Autoradiography,
pubmed-meshheading:1065173-Biopsy, Needle,
pubmed-meshheading:1065173-Breast Neoplasms,
pubmed-meshheading:1065173-Carcinoma,
pubmed-meshheading:1065173-Castration,
pubmed-meshheading:1065173-DNA,
pubmed-meshheading:1065173-Estradiol,
pubmed-meshheading:1065173-Female,
pubmed-meshheading:1065173-Humans,
pubmed-meshheading:1065173-Middle Aged,
pubmed-meshheading:1065173-Tamoxifen,
pubmed-meshheading:1065173-Thymidine
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pubmed:articleTitle |
3H-thymidine incorporation into mammary carcinoma cells obtained by needle aspiration before and during endocrine therapy.
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pubmed:publicationType |
Journal Article
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