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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-2-24
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pubmed:abstractText |
Cranial radiation therapy (CRT) has been suggested to be a principal factor responsible for long term neurocognitive deficits in survivors of acute lymphoblastic leukemia (ALL). However, neither reduction of the irradiation dose nor the elimination of irradiation entirely appear to have abolished neurocognitive impairment in long term ALL survivors. Positron emission tomography (PET) and [(18)F]-fluorodeoxyglucose (FDG) can be used to quantitate cerebral glucose metabolism, a potential indicator of treatment-induced adverse central nervous system (CNS) effects. The purpose of this study was to assess whether CRT is associated with defects in cerebral glucose metabolism in long term ALL survivors. The authors also studied whether chemotherapy and/or the severity of disease have deleterious effects on glucose metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:AärimaaTT,
pubmed-author:Harila-SaariAA,
pubmed-author:KähkönenMM,
pubmed-author:KorhonenTT,
pubmed-author:MetsähonkalaLL,
pubmed-author:MimsVV,
pubmed-author:Norvasuo-HeiläM KMK,
pubmed-author:RuotsalainenUU,
pubmed-author:SalmiT TTT,
pubmed-author:SolinOO,
pubmed-author:Suhonen-PolviHH,
pubmed-author:UtriainenTT
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pubmed:copyrightInfo |
Copyright 2000 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-700
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10649265-Adolescent,
pubmed-meshheading:10649265-Age Factors,
pubmed-meshheading:10649265-Antimetabolites, Antineoplastic,
pubmed-meshheading:10649265-Attention,
pubmed-meshheading:10649265-Brain,
pubmed-meshheading:10649265-Brain Diseases,
pubmed-meshheading:10649265-Brain Neoplasms,
pubmed-meshheading:10649265-Child,
pubmed-meshheading:10649265-Cranial Irradiation,
pubmed-meshheading:10649265-Female,
pubmed-meshheading:10649265-Fluorodeoxyglucose F18,
pubmed-meshheading:10649265-Glucose,
pubmed-meshheading:10649265-Humans,
pubmed-meshheading:10649265-Leukocyte Count,
pubmed-meshheading:10649265-Male,
pubmed-meshheading:10649265-Mental Processes,
pubmed-meshheading:10649265-Methotrexate,
pubmed-meshheading:10649265-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10649265-Psychomotor Performance,
pubmed-meshheading:10649265-Radiation Injuries,
pubmed-meshheading:10649265-Radiopharmaceuticals,
pubmed-meshheading:10649265-Radiotherapy Dosage,
pubmed-meshheading:10649265-Survivors,
pubmed-meshheading:10649265-Tomography, Emission-Computed
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pubmed:year |
2000
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pubmed:articleTitle |
Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia.
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pubmed:affiliation |
Turku Positron Emission Tomography Center, University of Turku, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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