Source:http://linkedlifedata.com/resource/pubmed/id/10627406
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2000-2-24
|
| pubmed:abstractText |
Prediction of post-surgical seizure relief and potential cognitive deficits secondary to anterior temporal lobectomy (ATL) are important to pre-surgical planning. Although the intracarotid amobarbital test (IAT) is predictive of post-ATL seizure outcome, development of non-invasive and more precise means for determining post-ATL seizure relief are needed. We previously reported on a technique utilizing functional MRI (fMRI) to evaluate the relative functional adequacy of mesial temporal lobe structures in preparation for ATL. In the present study, we report follow-up outcome data on eight temporal lobe epilepsy (TLE) patients 1-year post-ATL who were evaluated pre-surgically using IAT and fMRI. Functional memory lateralization using fMRI predicted post-ATL seizure outcome as effectively as the IAT. In general, asymmetry of functional mTL activation favouring the non-epileptic hemisphere was associated with seizure-free status at 1-year follow-up. Moreover, when combined, fMRI and IAT provided complementary data that resulted in improved prediction of post-operative seizure control compared with either procedure alone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1059-1311
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 BEA Trading Ltd.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
450-5
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10627406-Adolescent,
pubmed-meshheading:10627406-Adult,
pubmed-meshheading:10627406-Amobarbital,
pubmed-meshheading:10627406-Cognition Disorders,
pubmed-meshheading:10627406-Drug Administration Routes,
pubmed-meshheading:10627406-Epilepsy, Temporal Lobe,
pubmed-meshheading:10627406-Female,
pubmed-meshheading:10627406-Functional Laterality,
pubmed-meshheading:10627406-GABA Modulators,
pubmed-meshheading:10627406-Humans,
pubmed-meshheading:10627406-Magnetic Resonance Imaging,
pubmed-meshheading:10627406-Male,
pubmed-meshheading:10627406-Memory,
pubmed-meshheading:10627406-Postoperative Care,
pubmed-meshheading:10627406-Postoperative Complications,
pubmed-meshheading:10627406-Predictive Value of Tests,
pubmed-meshheading:10627406-Preoperative Care,
pubmed-meshheading:10627406-Psychosurgery,
pubmed-meshheading:10627406-Temporal Lobe
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control.
|
| pubmed:affiliation |
Department of Neurology, University of Pennsylvania Medical Center, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|