| pubmed-article:10626250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10626250 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:10626250 | lifeskim:mentions | umls-concept:C0598766 | lld:lifeskim |
| pubmed-article:10626250 | lifeskim:mentions | umls-concept:C0679006 | lld:lifeskim |
| pubmed-article:10626250 | lifeskim:mentions | umls-concept:C1540661 | lld:lifeskim |
| pubmed-article:10626250 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10626250 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10626250 | pubmed:dateCreated | 2000-1-24 | lld:pubmed |
| pubmed-article:10626250 | pubmed:abstractText | Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal regulator of normal differentiation of B and T lymphocytes as well as one of the most frequently translocated oncogenes in human B cell lymphomas. As an oncogene, BCL-6 has not been easy to place into existing paradigms of cellular transformation. Rather, it is likely that the function of BCL-6 as a regulator of lymphocyte differentiation is subverted in BCL-6-induced lymphomas. The lymphomas in which BCL-6 is translocated are all suspected to arise from the germinal center B lymphocyte. Given the selective expression of BCL-6 protein in normal germinal center B lymphocytes and the requirement for BCL-6 in germinal center development, the functions of BCL-6 in normal and malignant B cells are probably intertwined. The BCL-6 protein is a potent transcriptional repressor which presumably controls lymphocyte differentiation and induces lymphomas by regulating the expression of key downstream target genes. | lld:pubmed |
| pubmed-article:10626250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10626250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10626250 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10626250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10626250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10626250 | pubmed:issn | 0883-0185 | lld:pubmed |
| pubmed-article:10626250 | pubmed:author | pubmed-author:YuXX | lld:pubmed |
| pubmed-article:10626250 | pubmed:author | pubmed-author:ShafferA LAL | lld:pubmed |
| pubmed-article:10626250 | pubmed:author | pubmed-author:StaudtL MLM | lld:pubmed |
| pubmed-article:10626250 | pubmed:author | pubmed-author:DentA LAL | lld:pubmed |
| pubmed-article:10626250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10626250 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10626250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10626250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10626250 | pubmed:pagination | 381-403 | lld:pubmed |
| pubmed-article:10626250 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:10626250 | pubmed:meshHeading | pubmed-meshheading:10626250... | lld:pubmed |
| pubmed-article:10626250 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10626250 | pubmed:articleTitle | Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. | lld:pubmed |
| pubmed-article:10626250 | pubmed:affiliation | Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. lstaudt@box-1.nih.gov | lld:pubmed |
| pubmed-article:10626250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10626250 | pubmed:publicationType | Review | lld:pubmed |
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