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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027428,
umls-concept:C0040648,
umls-concept:C0040661,
umls-concept:C0185117,
umls-concept:C0304604,
umls-concept:C1280500,
umls-concept:C1335877,
umls-concept:C1515655,
umls-concept:C1705162,
umls-concept:C1710082,
umls-concept:C2607914,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-28
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pubmed:abstractText |
The allergen-induced late nasal response is associated with a high local expression of interleukin (IL) -4, a TH2-type cytokine implicated in immunoglobulin (Ig) E production, tissue eosinophilia and other events considered to be relevant to allergic inflammation. Interaction of IL-4 with its receptor activates at least two distinct signalling pathways that culminate in the transcription of specific target genes. One pathway involves the activation of a transcription factor termed signal transducer and activator of transcription factor 6 (STAT6).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Eosinophil Granule Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Steroids,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0954-7894
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10606935-Administration, Intranasal,
pubmed-meshheading:10606935-Allergens,
pubmed-meshheading:10606935-Anti-Inflammatory Agents,
pubmed-meshheading:10606935-Antigens, CD3,
pubmed-meshheading:10606935-Blood Proteins,
pubmed-meshheading:10606935-Bronchodilator Agents,
pubmed-meshheading:10606935-Double-Blind Method,
pubmed-meshheading:10606935-Eosinophil Granule Proteins,
pubmed-meshheading:10606935-Eosinophils,
pubmed-meshheading:10606935-Gene Expression Regulation,
pubmed-meshheading:10606935-Glucocorticoids,
pubmed-meshheading:10606935-Humans,
pubmed-meshheading:10606935-Interleukin-4,
pubmed-meshheading:10606935-Lymphocyte Count,
pubmed-meshheading:10606935-Nasal Mucosa,
pubmed-meshheading:10606935-RNA, Messenger,
pubmed-meshheading:10606935-Rhinitis, Allergic, Seasonal,
pubmed-meshheading:10606935-Ribonucleases,
pubmed-meshheading:10606935-STAT6 Transcription Factor,
pubmed-meshheading:10606935-Signal Transduction,
pubmed-meshheading:10606935-Steroids,
pubmed-meshheading:10606935-T-Lymphocytes,
pubmed-meshheading:10606935-Trans-Activators
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pubmed:year |
2000
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pubmed:articleTitle |
In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids.
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pubmed:affiliation |
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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