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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-1-4
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pubmed:abstractText |
Targeted disruption of either of the B cell-specific transcription factors Oct-2 or OCA-B/BOB-1/OBF-1 dramatically affects B cell terminal differentiation. The 3' enhancer of immunoglobulin heavy chain (IgH) locus is important for transcription of the locus in terminal plasma cells. Allele-specific suppression of mutant Oct-2 binding sites in this enhancer by a variant Oct-2 protein revealed that in a mature B cell line this enhancer was specifically dependent upon Oct-2, as contrasted to the closely related Oct-1 transcription factor. Phosphorylation of the Oct-2 protein was important for this activation and was synergistic for coactivation by the OCA-B factor. These results indicate that Oct-2 and OCA-B interact with the 3' enhancer in regulation of the IgH locus during B cell activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-guanidinoethyl)-5-isoquinolines...,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-2,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2af1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-26
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10591177-3' Untranslated Regions,
pubmed-meshheading:10591177-Alleles,
pubmed-meshheading:10591177-Animals,
pubmed-meshheading:10591177-B-Lymphocytes,
pubmed-meshheading:10591177-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10591177-DNA,
pubmed-meshheading:10591177-DNA-Binding Proteins,
pubmed-meshheading:10591177-Enhancer Elements, Genetic,
pubmed-meshheading:10591177-Enzyme Inhibitors,
pubmed-meshheading:10591177-Gene Expression Regulation,
pubmed-meshheading:10591177-Genistein,
pubmed-meshheading:10591177-Imidazoles,
pubmed-meshheading:10591177-Immunoglobulin Heavy Chains,
pubmed-meshheading:10591177-Isoquinolines,
pubmed-meshheading:10591177-Lipopolysaccharides,
pubmed-meshheading:10591177-Lymphocyte Activation,
pubmed-meshheading:10591177-Mice,
pubmed-meshheading:10591177-Mice, Knockout,
pubmed-meshheading:10591177-Mutagenesis, Site-Directed,
pubmed-meshheading:10591177-Octamer Transcription Factor-2,
pubmed-meshheading:10591177-Phosphorylation,
pubmed-meshheading:10591177-Protein Binding,
pubmed-meshheading:10591177-Protein Kinase C,
pubmed-meshheading:10591177-Protein Processing, Post-Translational,
pubmed-meshheading:10591177-Protein Structure, Tertiary,
pubmed-meshheading:10591177-Pyridines,
pubmed-meshheading:10591177-Recombinant Fusion Proteins,
pubmed-meshheading:10591177-Staurosporine,
pubmed-meshheading:10591177-Structure-Activity Relationship,
pubmed-meshheading:10591177-Sulfonamides,
pubmed-meshheading:10591177-Trans-Activators,
pubmed-meshheading:10591177-Transcription Factors,
pubmed-meshheading:10591177-Transcriptional Activation,
pubmed-meshheading:10591177-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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