Source:http://linkedlifedata.com/resource/pubmed/id/10545390
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1999-12-10
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pubmed:abstractText |
In experimental animal models of multiple sclerosis demyelinating antibody responses are directed against the myelin oligodendrocyte glycoprotein (MOG). We have investigated whether a similar antibody response is also present in multiple sclerosis patients. Using the recombinant human extracellular immunoglobulin domain of MOG (MOG-Ig) we have screened the sera and CSFs of 130 multiple sclerosis patients, 32 patients with other inflammatory neurological diseases (OIND), 30 patients with other non-inflammatory neurological diseases (ONND) and 10 patients with rheumatoid arthritis. We report that 38% of multiple sclerosis patients are seropositive for IgG antibodies to MOG-Ig compared with 28% seropositive for anti-myelin basic protein (MBP). In contrast, OIND are characterized by similar frequencies of serum IgG antibody responses to MOG-Ig (53%) and MBP (47%), whereas serum IgG responses to MOG-Ig are rare in ONND (3%) and rheumatoid arthritis (10%). Anti-MBP IgG antibodies, however, are a frequent finding in ONND (23%) and rheumatoid arthritis (60%). Our results provide clear evidence that anti-MOG-Ig antibodies are common in CNS inflammation. However, in OIND these antibody responses are transient, whereas they persist in multiple sclerosis. We demonstrate that the serum anti-MOG-Ig response is already established in early multiple sclerosis (multiple sclerosis-R0; 36%). In later multiple sclerosis stages frequencies and titres are comparable with early multiple sclerosis. In contrast, the frequency of anti-MBP antibodies is low in multiple sclerosis-R0 (12%) and increases during disease progression in relapsing-remitting (32%) and chronic progressive multiple sclerosis (40%), thus suggesting that anti-MBP responses accumulate over time. Finally we provide evidence for intrathecal synthesis of IgG antibodies to MOG-Ig in multiple sclerosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/myelin oligodendrocyte glycoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-8950
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
122 ( Pt 11)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2047-56
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10545390-Adult,
pubmed-meshheading:10545390-Arthritis, Rheumatoid,
pubmed-meshheading:10545390-Autoantibodies,
pubmed-meshheading:10545390-Blotting, Western,
pubmed-meshheading:10545390-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10545390-Female,
pubmed-meshheading:10545390-Humans,
pubmed-meshheading:10545390-Immunoglobulins,
pubmed-meshheading:10545390-Male,
pubmed-meshheading:10545390-Middle Aged,
pubmed-meshheading:10545390-Multiple Sclerosis,
pubmed-meshheading:10545390-Myelin Basic Proteins,
pubmed-meshheading:10545390-Myelin Proteins,
pubmed-meshheading:10545390-Myelin-Associated Glycoprotein,
pubmed-meshheading:10545390-Nervous System Diseases,
pubmed-meshheading:10545390-Neuritis,
pubmed-meshheading:10545390-Recombinant Proteins,
pubmed-meshheading:10545390-Retrospective Studies
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pubmed:year |
1999
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pubmed:articleTitle |
Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study.
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pubmed:affiliation |
Department of Neurology, University of Innsbruck, Innsbruck, Austria and Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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